Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Study of Outcome and Safety of Lithium, Divalproex and Risperidone for Mania in Children and Adolescents
- Conditions
- Interventions
- First Posted Date
- 2003-04-08
- Last Posted Date
- 2013-04-04
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 379
- Registration Number
- NCT00057681
- Locations
- 🇺🇸
University of Pittsburgh/WPIC, Pittsburgh, Pennsylvania, United States
🇺🇸Johns Hopkins Medical Center, Baltimore, Maryland, United States
🇺🇸Children's National Medical Center, Washington, District of Columbia, United States
The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients.
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2008-07-30
- Target Recruit Count
- 6
- Registration Number
- NCT00000629
- Locations
- 🇺🇸
Tulane Univ Med School, New Orleans, Louisiana, United States
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
- Conditions
- First Posted Date
- 2001-03-15
- Last Posted Date
- 2007-05-04
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 5000
- Registration Number
- NCT00012558
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment
- Conditions
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 30
- Registration Number
- NCT00004758
Drug Treatment for Alcoholics With Bipolar Disorder
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2018-01-18
- Target Recruit Count
- 72
- Registration Number
- NCT00000439
- Locations
- 🇺🇸
Department of Psychiatry, Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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