Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
A Study to Evaluate the Effects of Lithium and Valproic Acid on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium and Valproic Acid in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2024-12-12
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Karuna Therapeutics
- Target Recruit Count
- 88
- Registration Number
- NCT06729970
- Locations
- 🇺🇸
Site 0001, Princeton, New Jersey, United States
Levetiracetam Versus Valproate in Idiopathic Generalized Epilepsy
- Conditions
- Interventions
- First Posted Date
- 2024-05-01
- Last Posted Date
- 2024-05-02
- Lead Sponsor
- Mazandaran University of Medical Sciences
- Target Recruit Count
- 169
- Registration Number
- NCT06393309
- Locations
- 🇮🇷
Bu Ali Sina Hospital, Sari, Mazandaran, Iran, Islamic Republic of
Valproate Versus Topiramate in Migraine
- First Posted Date
- 2024-02-08
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- Kafrelsheikh University
- Target Recruit Count
- 600
- Registration Number
- NCT06248931
- Locations
- 🇪🇬
Kafr Elsheikh University Hospital, Kafr Ash Shaykh, Egypt
Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects.
- First Posted Date
- 2024-01-18
- Last Posted Date
- 2024-01-22
- Lead Sponsor
- Desitin Arzneimittel GmbH
- Target Recruit Count
- 28
- Registration Number
- NCT06211283
- Locations
- 🇨🇦
Biopharma Services INC, Toronto, Canada
A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients
- Conditions
- Interventions
- First Posted Date
- 2024-01-10
- Last Posted Date
- 2024-01-10
- Lead Sponsor
- Haukeland University Hospital
- Target Recruit Count
- 48
- Registration Number
- NCT06199557
- Locations
- 🇳🇴
Haukeland University Hospital, Bergen, Norway
Zolmitriptane as Prophylaxis for Chilhood Migraine
- First Posted Date
- 2023-10-18
- Last Posted Date
- 2023-10-18
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT06089356
- Locations
- 🇪🇬
Kafrelsheikh University, Tanta, Kafrelsheikh, Egypt
Sodium Valproate in Patients With Acute Ischemic Stroke
- Conditions
- Interventions
- First Posted Date
- 2023-09-01
- Last Posted Date
- 2024-02-21
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT06020898
- Locations
- 🇨🇳
Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China
Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients
- Conditions
- Interventions
- First Posted Date
- 2023-04-20
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- National Cancer Institute, Naples
- Target Recruit Count
- 240
- Registration Number
- NCT05821556
- Locations
- 🇮🇹
Università vita e Salute, IRCCS San Raffaele, Milano, Italy
🇮🇹Istituto Nazionale Tumori di Napoli - IRCCS - Fondazione G. Pascale, Napoli, Italy
🇮🇹University of Verona Hospital Trust, Verona, Italy
The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children
- Conditions
- Interventions
- First Posted Date
- 2023-01-26
- Last Posted Date
- 2023-01-26
- Lead Sponsor
- Dr Cipto Mangunkusumo General Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT05697614
- Locations
- 🇮🇩
Cipto Mangunkusumo Hospital, Jakarta Pusat, Jakarta, Indonesia
🇮🇩Harapan Kita Hospital, Jakarta, Indonesia
🇮🇩Fatmawati Hospital, Jakarta, Indonesia
Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2023-01-23
- Last Posted Date
- 2023-11-03
- Lead Sponsor
- Australasian Gastro-Intestinal Trials Group
- Target Recruit Count
- 90
- Registration Number
- NCT05694936
- Locations
- 🇦🇺
Eben-Marie Garzina, Ballarat Central, Victoria, Australia
🇦🇺Southern Adelaide Local Health Network Incorporated, Bedford Park, South Australia, Australia
🇦🇺Austin Health, Melbourne, Victoria, Australia
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.