Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
The Val-CARD Trial
- Conditions
- Interventions
- First Posted Date
- 2019-01-31
- Last Posted Date
- 2023-11-13
- Lead Sponsor
- University of Leicester
- Target Recruit Count
- 122
- Registration Number
- NCT03825250
- Locations
- 🇬🇧
Glenfield Hospital, Leicester, Leicestershire, United Kingdom
Study of Excretion Balance and Pharmacokinetics of [14C]-Sodium Valproate (3.7 MBq) in Healthy Postmenopausal or Permanently Sterile Female Subjects
- First Posted Date
- 2018-09-21
- Last Posted Date
- 2022-04-25
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 5
- Registration Number
- NCT03681158
- Locations
- 🇬🇧
Investigational site number, Nottingham, United Kingdom
Pharmacokinetics of Antiepileptics in Patients on CRRT
- First Posted Date
- 2018-08-16
- Last Posted Date
- 2021-10-05
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 18
- Registration Number
- NCT03632915
- Locations
- 🇺🇸
University of Maryland Medical Center, Baltimore, Maryland, United States
LRAs United as a Novel Anti-HIV Strategy.
- First Posted Date
- 2018-05-16
- Last Posted Date
- 2021-04-29
- Lead Sponsor
- Erasmus Medical Center
- Target Recruit Count
- 28
- Registration Number
- NCT03525730
- Locations
- 🇳🇱
Erasmus MC, Rotterdam, Netherlands
Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074
- First Posted Date
- 2017-12-28
- Last Posted Date
- 2018-04-20
- Lead Sponsor
- Biogen
- Target Recruit Count
- 30
- Registration Number
- NCT03385525
- Locations
- 🇺🇸
Research Site, Dallas, Texas, United States
Avelumab With Valproic Acid in Virus-associated Cancer
- Conditions
- p16 Positive Squamous Cell Carcinoma of the Vagina or Vulvap16 Positive Squamous Cell Carcinoma of the Anus or Anal CanalSquamous Cell Carcinoma of the CervixCancer That is Associated With a Chronic Viral InfectionEBER Positive Hodgkins and Non-hodgkins Lymphonap16 Positive SCCHNp16 Positive Squamous Cell Carcinoma of the PenisEBER Positive NPC
- Interventions
- First Posted Date
- 2017-11-30
- Last Posted Date
- 2023-10-11
- Lead Sponsor
- AHS Cancer Control Alberta
- Target Recruit Count
- 39
- Registration Number
- NCT03357757
- Locations
- 🇨🇦
Cross Cancer Institute, Edmonton, Alberta, Canada
Assessment of Valproate on Ethanol Withdrawal
- Conditions
- Interventions
- First Posted Date
- 2017-08-01
- Last Posted Date
- 2017-08-01
- Lead Sponsor
- CAMC Health System
- Target Recruit Count
- 210
- Registration Number
- NCT03235531
- Locations
- 🇺🇸
Charleston Area Medical Center, Charleston, West Virginia, United States
🇺🇸Charleston Area Medical Center, General Hospital, Level 1 Trauma Center, Charleston, West Virginia, United States
Population Pharmacokinetics of Antiepileptic in Pediatrics
- Conditions
- Interventions
- Biological: Valproic acidBiological: carbamazepineBiological: phenobarbitalBiological: phenytoinBiological: levetiracetamBiological: lamotrigineBiological: topiramateBiological: oxcarbazepineBiological: stiripentolBiological: clobazamBiological: brivaracétamBiological: felbamateBiological: lacosamideBiological: rufinamideBiological: gabapentineBiological: pregabalineBiological: sultiameBiological: tiagabineBiological: vigabatrineBiological: mesuximideBiological: primidoneBiological: perampanelBiological: ethosuximideBiological: zonisamideBiological: cannabidiolOther: genetic polymorphisms
- First Posted Date
- 2017-06-22
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 1000
- Registration Number
- NCT03196466
- Locations
- 🇫🇷
AP-HP Cochin, Paris, France
Sodium Valproate for GSDV
- Conditions
- Interventions
- First Posted Date
- 2017-04-13
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- University College, London
- Target Recruit Count
- 8
- Registration Number
- NCT03112889
- Locations
- 🇬🇧
MRC Centre for Neuromuscular Diseases, London, United Kingdom
🇩🇰Rigshospitalet, Copenhagen, Denmark
Seizure Treatment in Glioma
- First Posted Date
- 2017-02-09
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- Leiden University Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT03048084
- Locations
- 🇳🇱
VU University Medical Center, Amsterdam, Netherlands
🇳🇱Medisch Spectrum Twente, Enschede, Netherlands
🇳🇱Leiden University Medical Center, Leiden, Netherlands
Drug Development Updates
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