Valproic acid

Generic Name
Valproic acid
Brand Names
Depakene, Depakote, Epival
Drug Type
Small Molecule
Chemical Formula
C8H16O2
CAS Number
99-66-1
Unique Ingredient Identifier
614OI1Z5WI
Background

Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...

Indication

Indicated for:

1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.

2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.

3) Prophylaxis of migraine headaches.

4) Acute management of mania associated with bipolar disorder.
...

Associated Conditions
Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
Associated Therapies
-
Clinical Trials
Related News

Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma

First Posted Date
2016-01-07
Last Posted Date
2017-05-31
Lead Sponsor
University of Virginia
Target Recruit Count
4
Registration Number
NCT02648633
Locations
🇺🇸

University of Virginia, Charlottesville, Virginia, United States

Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck

First Posted Date
2015-12-08
Last Posted Date
2023-11-13
Lead Sponsor
National Cancer Institute, Naples
Target Recruit Count
39
Registration Number
NCT02624128
Locations
🇮🇹

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Italy

Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid

First Posted Date
2015-11-20
Last Posted Date
2018-02-01
Lead Sponsor
Barretos Cancer Hospital
Target Recruit Count
42
Registration Number
NCT02608736
Locations
🇧🇷

Barretos Cancer Hospital, Barretos, São Paulo, Brazil

Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer

First Posted Date
2015-08-11
Last Posted Date
2019-08-14
Lead Sponsor
Barbara Ann Karmanos Cancer Institute
Target Recruit Count
50
Registration Number
NCT02520115
Locations
🇺🇸

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

🇺🇸

Karmanos Cancer Institute at McLaren Bay Region, Bay City, Bay City, Michigan, United States

Controlled Trial of Valproate Versus Risperidone in Young Children With Bipolar Disorder

First Posted Date
2015-05-28
Last Posted Date
2018-12-12
Lead Sponsor
Nationwide Children's Hospital
Target Recruit Count
46
Registration Number
NCT02456454

Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence

First Posted Date
2015-05-18
Last Posted Date
2015-05-18
Lead Sponsor
Miller Children's & Women's Hospital Long Beach
Target Recruit Count
20
Registration Number
NCT02446431
Locations
🇺🇸

Miller Children's and Women's Hospital Long Beach, Long Beach, California, United States

🇺🇸

Children's Hospital Orange County, Orange, California, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU

First Posted Date
2015-01-22
Last Posted Date
2019-06-26
Lead Sponsor
Stanford University
Target Recruit Count
3
Registration Number
NCT02343575
Locations
🇺🇸

Stanford Hospital and Clinics, Stanford, California, United States

Pretreatment With Valproate Prior to Immunotherapy Targeting Cluster of Differentiation Antigen 20 in Chronic Lymphocytic Leukemia

Early Phase 1
Completed
Conditions
Chronic Lymphocytic Leukemia
Interventions
Drug: Valproate
First Posted Date
2014-05-22
Last Posted Date
2017-03-03
Lead Sponsor
Lund University Hospital
Target Recruit Count
4
Registration Number
NCT02144623
Locations
🇸🇪

Lund University Hospital, Department of Oncology, Lund, Sweden

Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma

First Posted Date
2014-02-21
Last Posted Date
2024-03-15
Lead Sponsor
Sidney Kimmel Cancer Center at Thomas Jefferson University
Target Recruit Count
210
Registration Number
NCT02068586
Locations
🇺🇸

Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States

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