Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Six Month Trial of Lamotrigine vs. Sodium Valproate for Treatment of Mixed Mania
- Conditions
- First Posted Date
- 2005-09-21
- Last Posted Date
- 2010-11-25
- Lead Sponsor
- Beth Israel Medical Center
- Target Recruit Count
- 36
- Registration Number
- NCT00206778
- Locations
- 🇺🇸
Beth Israel Medical Center, New York, New York, United States
Study of Depakote for Behavioral and Psychological Symptoms in Dementia
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2006-08-15
- Lead Sponsor
- Hearthstone Alzheimer Care
- Target Recruit Count
- 20
- Registration Number
- NCT00197834
- Locations
- 🇺🇸
Hearthstone at Golden Pond, Hopkinton, Massachusetts, United States
Treatment With ATRA-IV and Depakote in Patients With Advanced Solid Tumor Malignancies
- Conditions
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2006-09-14
- Lead Sponsor
- Weill Medical College of Cornell University
- Registration Number
- NCT00195156
- Locations
- 🇺🇸
Weill Medical College of Cornell University, New York, New York, United States
Valproate in Late Life Schizophrenia
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2015-01-06
- Lead Sponsor
- University Hospitals Cleveland Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT00194025
- Locations
- 🇺🇸
University Hospitals of Cleveland, Cleveland, Ohio, United States
Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal Carcinoma
- Conditions
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2020-05-18
- Lead Sponsor
- Johns Hopkins University
- Registration Number
- NCT00181220
- Locations
- 🇸🇬
Johns Hopkin Singapore International Medical Center, Singapore, Singapore
Differentiation Induction in Acute Myelogenous Leukemia
- Conditions
- Interventions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2015-06-24
- Lead Sponsor
- University of Bergen
- Target Recruit Count
- 24
- Registration Number
- NCT00175812
- Locations
- 🇳🇴
Haukeland University Hospital, University of Bergen, Bergen, Norway
Determining Metabolic Effects of Valproate and Antipsychotic Therapy
- First Posted Date
- 2005-09-14
- Last Posted Date
- 2020-02-10
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 164
- Registration Number
- NCT00167934
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Study of Efficacy of Sodium Valproate in Therapy of Bronchial Asthma
- Conditions
- First Posted Date
- 2005-09-12
- Last Posted Date
- 2009-02-19
- Lead Sponsor
- Centre of Chinese Medicine, Georgia
- Target Recruit Count
- 46
- Registration Number
- NCT00153270
Seroquel in Acute Mania: Study to Investigate if Valproate Add-On Therapy is Superior to Quetiapine Monotherapy in Acutely Manic Patients
- Conditions
- Interventions
- First Posted Date
- 2005-08-31
- Last Posted Date
- 2013-01-28
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 17
- Registration Number
- NCT00139074
- Locations
- 🇩🇰
Research Site, Kolding, Denmark
🇩🇰Researcg Site, Svendborg, Denmark
Hormone Profiles in Adults With Newly Diagnosed Epilepsy
- Conditions
- First Posted Date
- 2005-08-30
- Last Posted Date
- 2007-10-31
- Lead Sponsor
- Chinese University of Hong Kong
- Target Recruit Count
- 80
- Registration Number
- NCT00137709
- Locations
- 🇭🇰
Prince of Wales Hospital, Shatin, Hong Kong
🇭🇰United Christian Hospital, Kowloon, Hong Kong
Drug Development Updates
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