Valproic acid
- Generic Name
- Valproic acid
- Brand Names
- Depakene, Depakote, Epival
- Drug Type
- Small Molecule
- Chemical Formula
- C8H16O2
- CAS Number
- 99-66-1
- Unique Ingredient Identifier
- 614OI1Z5WI
- Background
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant effects o...
- Indication
Indicated for:
1) Use as monotherapy or adjunctive therapy in the management of complex partial seizures and simple or complex absence seizures.
2) Adjunctive therapy in the management of multiple seizure types that include absence seizures.
3) Prophylaxis of migraine headaches.
4) Acute management of mania associated with bipolar disorder.
...
- Associated Conditions
- Bipolar Disorder (BD), Complex Partial Seizure Disorder, Depressive Episodes, Migraine, Petit Mal Epilepsy, Seizure, multiple types, Acute Manic episode
- Associated Therapies
- -
Phase II 5-Azacytidine Plus VPA Plus ATRA
- Conditions
- Interventions
- First Posted Date
- 2006-05-16
- Last Posted Date
- 2012-06-15
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 34
- Registration Number
- NCT00326170
- Locations
- 🇺🇸
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
Study of Valproic Acid to Treat HIV Infected Adults
- First Posted Date
- 2006-04-10
- Last Posted Date
- 2012-05-14
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 14
- Registration Number
- NCT00312546
- Locations
- 🇺🇸
University of North Carolina Memorial Hospital, Chapel Hill, North Carolina, United States
Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors
- Conditions
- Interventions
- First Posted Date
- 2006-03-13
- Last Posted Date
- 2016-08-18
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 43
- Registration Number
- NCT00302159
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
🇺🇸National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇺🇸University of Pennsylvania, Philadelphia, Pennsylvania, United States
A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights
- Conditions
- First Posted Date
- 2006-03-03
- Last Posted Date
- 2012-07-03
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 22
- Registration Number
- NCT00298857
- Locations
- 🇺🇸
Long Island Jewish Medical Center, New Hyde Park, New York, United States
Valproic Acid and Its Effects on HIV Latent Reservoirs
- First Posted Date
- 2006-02-10
- Last Posted Date
- 2023-03-15
- Lead Sponsor
- Jean-Pierre Routy
- Target Recruit Count
- 50
- Registration Number
- NCT00289952
- Locations
- 🇨🇦
BC St-Paul's Hospital/Immunodeficiency Clinic, Vancouver, British Columbia, Canada
🇨🇦Actuel Medical Clinic, Montreal, Quebec, Canada
🇨🇦Quartier Latin Medical Clinic, Montreal, Quebec, Canada
Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder
- Conditions
- Interventions
- First Posted Date
- 2005-12-19
- Last Posted Date
- 2010-12-28
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 139
- Registration Number
- NCT00266630
- Locations
- 🇯🇵
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Tokyo, Japan
Spanish Validation Of Quality of Life Questionnaire (QOLIE-10) For Epilepsy
- Conditions
- First Posted Date
- 2005-12-13
- Last Posted Date
- 2017-10-30
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 333
- Registration Number
- NCT00264680
Phase I Trial of Valproic Acid and Epirubicin in Solid Tumor Malignancies
- Conditions
- Interventions
- First Posted Date
- 2005-10-30
- Last Posted Date
- 2017-02-23
- Target Recruit Count
- 82
- Registration Number
- NCT00246103
- Locations
- 🇺🇸
H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States
Valproate Efficacy in Cocaine-Bipolar Comorbidity
- Conditions
- Interventions
- First Posted Date
- 2005-10-17
- Last Posted Date
- 2016-10-17
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 152
- Registration Number
- NCT00240110
- Locations
- 🇺🇸
University of Miami Miller School of Medicine, Miami, Florida, United States
🇺🇸University of Miami Miller School of Medicine, Department of Psychiatry, Miami, Florida, United States
Efficacy of Valproate in Peripheral Neuropathic Pain
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2007-06-13
- Lead Sponsor
- University Hospital, Bordeaux
- Target Recruit Count
- 40
- Registration Number
- NCT00221637
- Locations
- 🇫🇷
Unité de traitement de la douleur chronique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France
Drug Development Updates
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