Acetazolamide

Generic Name
Acetazolamide
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C4H6N4O3S2
CAS Number
59-66-5
Unique Ingredient Identifier
O3FX965V0I
Background

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of...

Indication

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Associated Conditions
Acute angle-closure glaucoma, Edema, Familial periodic paralysis, Generalized Tonic-Clonic Seizures, Metabolic Alkalosis, Open Angle Glaucoma (OAG), Other and unspecified effects of high altitude, Cystine renal calculi, Drug-induced edema, Nonuveitic secondary glaucoma, Salicylate intoxication
Associated Therapies
Urine alkalinization therapy
Clinical Trials
Related News

Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure

First Posted Date
2013-08-15
Last Posted Date
2013-08-15
Lead Sponsor
Siriraj Hospital
Target Recruit Count
15
Registration Number
NCT01923454
Locations
🇹🇭

Naris Kitnarong, Bangkok, Thailand

Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery

Phase 4
Conditions
Thoracic Aneurysm
Interventions
Drug: Acetazolamide
First Posted Date
2013-06-28
Last Posted Date
2014-12-31
Lead Sponsor
Liverpool Heart and Chest Hospital NHS Foundation Trust
Target Recruit Count
100
Registration Number
NCT01889498
Locations
🇬🇧

Liverpool heart & chest hospital, Liverpool, United Kingdom

🇬🇧

Liverpool Heart & Chest Hospital, Liverpool, United Kingdom

Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence

First Posted Date
2013-06-03
Last Posted Date
2015-04-21
Lead Sponsor
Tehran University of Medical Sciences
Target Recruit Count
144
Registration Number
NCT01867268
Locations
🇮🇷

Children'S Medical Center, Tehran, Iran, Islamic Republic of

Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Phase 1
Completed
Conditions
Cocaine Use
Pharmacokinetics
First Posted Date
2013-05-10
Last Posted Date
2018-07-05
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Target Recruit Count
14
Registration Number
NCT01851473
Locations
🇺🇸

National Institute on Drug Abuse, Baltimore, Maryland, United States

Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Not Applicable
Completed
Conditions
Migraine
Headache
Interventions
Drug: Acetazolamide
First Posted Date
2012-12-17
Last Posted Date
2013-07-09
Lead Sponsor
Danish Headache Center
Target Recruit Count
12
Registration Number
NCT01750723
Locations
🇩🇰

Department of Neurology, Copenhagen, Glostrup, Denmark

🇩🇰

Danish Headache Center, Copenhagen, Glostrup, Denmark

Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

First Posted Date
2012-06-26
Last Posted Date
2015-10-06
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
380
Registration Number
NCT01627639
Locations
🇫🇷

Clinical Research Unit, European Georges Pompidou Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France

Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude

Not Applicable
Completed
Conditions
High-altitude Sleep Disturbance
Interventions
Drug: Acetazolamide
Drug: Temazepam
First Posted Date
2012-01-27
Last Posted Date
2015-04-23
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
34
Registration Number
NCT01519544
Locations
🇳🇵

Himalayan Rescue Location clinic in Manang, Manang, District of Manang, Nepal

Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.

First Posted Date
2011-12-26
Last Posted Date
2015-03-17
Lead Sponsor
Hospital Son Llatzer
Target Recruit Count
140
Registration Number
NCT01499485
Locations
🇪🇸

Hospital de Manacor, Manacor, Illes Balears, Spain

🇪🇸

Fundación Jiménez Díaz, Madrid, Comunidad de Madrid, Spain

🇪🇸

Hospital Son Espases, Palma de Mallorca, Illes Balears, Spain

and more 5 locations

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

First Posted Date
2011-09-01
Last Posted Date
2012-12-12
Lead Sponsor
University of Zurich
Target Recruit Count
23
Registration Number
NCT01427192
Locations
🇨🇭

Respiratory Clinic, University Hospital of Zurich, Zurich, Switzerland

A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent

Phase 4
Completed
Conditions
Acute Mountain Sickness
Interventions
Drug: Placebo
Drug: Acetazolamide
First Posted Date
2011-08-16
Last Posted Date
2013-06-24
Lead Sponsor
Oxford University Clinical Research Unit, Vietnam
Target Recruit Count
380
Registration Number
NCT01418157
Locations
🇳🇵

Oxford University Clinical Research Unit Nepal, Kathmandu, Nepal

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