Mannitol

Generic Name: Mannitol

Brand Names: Aridol, Bronchitol, Cystosol, Osmitrol, Sag-M

Drug Type: Small Molecule

Chemical Formula: C_₆H_₁₄O_₆

CAS Number: 69-65-8

Unique Ingredient Identifier: 3OWL53L36A

Background: Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated i...

Indication: Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
...

Associated Conditions: Acute Renal Failure (ARF), Cystic Fibrosis (CF), Edema of the cerebrum, Increased Intra Ocular Pressure (IOP)

Associated Therapies: Bladder irrigation therapy

Clinical Trials

Comparison of Two Doses of Mannitol on Brain Relaxation During Supratentorial Craniotomy

Not Applicable

Completed

Conditions: Brain Tumor
Intracranial Pressure

Interventions: Drug: Mannitol

First Posted Date: 2010-01-14

Last Posted Date: 2011-05-05

Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Target Recruit Count: 80

Registration Number: NCT01048684

Locations: 🇨🇦
Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame, Montreal, Quebec, Canada

Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values

Phase 3

Terminated

Conditions: Traumatic Brain Injury

Interventions: Drug: Hypertonic saline
Drug: Mannitol

First Posted Date: 2009-12-09

Last Posted Date: 2012-08-08

Lead Sponsor: Direction Centrale du Service de Santé des Armées

Target Recruit Count: 30

Registration Number: NCT01028339

Locations: 🇫🇷
HIA Sainte Anne, Toulon, France

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Phase 1

Conditions: Germ Cell Tumor
Recurrent Medulloblastoma
Embryonal Tumor With Multilayered Rosettes, C19MC-Altered
Medulloblastoma
Medulloepithelioma
Recurrent Malignant Germ Cell Tumor
Recurrent Primitive Neuroectodermal Tumor
Primitive Neuroectodermal Tumor
Central Nervous System Embryonal Neoplasm
Recurrent Childhood Central Nervous System Embryonal Neoplasm

Interventions: Drug: Carboplatin
Drug: Mannitol
Drug: Melphalan
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
Drug: Sodium Thiosulfate

First Posted Date: 2009-09-24

Last Posted Date: 2021-10-26

Lead Sponsor: OHSU Knight Cancer Institute

Target Recruit Count: 17

Registration Number: NCT00983398

Locations: 🇺🇸
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States
🇺🇸
OHSU Knight Cancer Institute, Portland, Oregon, United States

Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury

Phase 1

Conditions: Severe Head Trauma

Interventions: Drug: AbelaDrug200
Drug: mannitol

First Posted Date: 2008-12-18

Last Posted Date: 2010-12-08

Lead Sponsor: Abela Pharmaceuticals, Inc.

Target Recruit Count: 30

Registration Number: NCT00810940

Locations: 🇺🇸
University of California, Irvine, Irvine, California, United States
🇺🇸
Boston University Medical Center, Boston, Massachusetts, United States
🇺🇸
Ohio State University, Columbus, Ohio, United States

Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients

Phase 1

Completed

Conditions: Cystic Fibrosis

First Posted Date: 2008-11-18

Last Posted Date: 2010-02-02

Lead Sponsor: Syntara

Target Recruit Count: 18

Registration Number: NCT00792714

Locations: 🇬🇧
Southampton General Hospital, Southampton, United Kingdom
🇬🇧
Sheffield Children's Clinical Foundation, Sheffield, United Kingdom
🇦🇺
Mater Adult Hospital, Brisbane, Queensland, Australia

and more 1 locations

Effects of Copaxone in the Retinal Function in Diabetic Patients After Panphotocoagulation

Phase 4

Conditions: Diabetic Retinopathy

Interventions: Drug: Glatiramer acetate (Copaxone)
Drug: Mannitol

First Posted Date: 2008-05-14

Last Posted Date: 2008-05-14

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 30

Registration Number: NCT00677664

Locations: 🇧🇷
Federal University of Sao Paulo, Sao Paulo, SP, Brazil

Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN

Early Phase 1

Completed

Conditions: Asthma

Interventions: Drug: mannitol

First Posted Date: 2008-01-03

Last Posted Date: 2019-08-19

Lead Sponsor: University of Wisconsin, Madison

Target Recruit Count: 66

Registration Number: NCT00585260

Locations: 🇺🇸
University of Wisconsin Madison Department of Asthma, Allergy and Pulmonary Clinical Research, Madison, Wisconsin, United States

Study of the Pathogenesis and Molecular Mechanism of "YURE" in Internal Intractable Diseases

Phase 2

Conditions: Stroke

Interventions: Drug: Chinese herbs formula
Drug: Mannitol

First Posted Date: 2007-12-06

Last Posted Date: 2009-07-08

Lead Sponsor: Nanjing University of Traditional Chinese Medicine

Target Recruit Count: 300

Registration Number: NCT00569088

Locations: 🇨🇳
Institute of Internal Intractable Diseases, Nanjing University of Traditonal Chinese Medicine, Nanjing, Jiangsu, China

A Pharmacokinetic and Bioavailability Study of Mannitol for Inhalation Using Normal Subjects

Phase 1

Completed

Conditions: Healthy Volunteers

First Posted Date: 2007-03-13

Last Posted Date: 2007-03-13

Lead Sponsor: Syntara

Target Recruit Count: 18

Registration Number: NCT00446771

Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study

Phase 3

Completed

Conditions: Cystic Fibrosis

Interventions: Drug: placebo
Drug: Mannitol

First Posted Date: 2007-03-13

Last Posted Date: 2010-06-25

Lead Sponsor: Syntara

Target Recruit Count: 340

Registration Number: NCT00446680

Locations: 🇮🇪
National Children's Hospital, Dublin, Ireland
🇮🇪
Our Lady's Hospital for Sick Children, Dublin, Ireland
🇦🇺
Royal Childrens Hospital, Melbourne, Victoria, Australia

and more 26 locations

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