Mannitol
- Generic Name
- Mannitol
- Brand Names
- Aridol, Bronchitol, Cystosol, Osmitrol, Sag-M
- Drug Type
- Small Molecule
- Chemical Formula
- C6H14O6
- CAS Number
- 69-65-8
- Unique Ingredient Identifier
- 3OWL53L36A
- Background
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated i...
- Indication
Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
...
- Associated Conditions
- Acute Renal Failure (ARF), Cystic Fibrosis (CF), Edema of the cerebrum, Increased Intra Ocular Pressure (IOP)
- Associated Therapies
- Bladder irrigation therapy
A Pilot Safety Study of Inhaled Dry Powder Mannitol in Acute Exacerbations of COPD
- First Posted Date
- 2007-03-13
- Last Posted Date
- 2016-09-28
- Lead Sponsor
- Syntara
- Registration Number
- NCT00446667
- Locations
- 🇦🇺
St George Hospital, Sydney, New South Wales, Australia
🇦🇺Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
- Conditions
- First Posted Date
- 2006-10-20
- Last Posted Date
- 2008-06-03
- Lead Sponsor
- Rocky Mountain Cancer Centers
- Target Recruit Count
- 20
- Registration Number
- NCT00390624
- Locations
- 🇺🇸
Rocky Mountain Cancer Centers 1800 Williams Street, Suite 200, Denver, Colorado, United States
Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors
- Conditions
- Interventions
- First Posted Date
- 2006-03-17
- Last Posted Date
- 2022-03-17
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 33
- Registration Number
- NCT00303849
- Locations
- 🇺🇸
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States
🇺🇸OHSU Knight Cancer Institute, Portland, Oregon, United States
Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
- First Posted Date
- 2006-02-17
- Last Posted Date
- 2021-09-22
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 81
- Registration Number
- NCT00293475
- Locations
- 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States
🇺🇸Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
🇺🇸Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States
Safety and Efficacy of Bronchitol in Bronchiectasis
- First Posted Date
- 2006-01-16
- Last Posted Date
- 2008-08-29
- Lead Sponsor
- Syntara
- Target Recruit Count
- 354
- Registration Number
- NCT00277537
- Locations
- 🇦🇺
Royal Perth Hospital, Perth, Western Australia, Australia
🇬🇧Belfast City Hospital, Belfast, Northern Ireland, United Kingdom
🇦🇺St George Hospital, Kogarah, New South Wales, Australia
Ability of Aridol to Detect Bronchial Hyperresponsiveness in Suspected Asthmatics
- Conditions
- First Posted Date
- 2005-11-11
- Last Posted Date
- 2009-12-01
- Lead Sponsor
- Syntara
- Target Recruit Count
- 240
- Registration Number
- NCT00252291
- Locations
- 🇺🇸
Colorado Asthma and Allergy Centers, 125 Rampart Way, Denver, Colorado, United States
Mannitol Dose Response Study in Cystic Fibrosis
- First Posted Date
- 2005-11-09
- Last Posted Date
- 2008-08-29
- Lead Sponsor
- Syntara
- Target Recruit Count
- 48
- Registration Number
- NCT00251056
- Locations
- 🇨🇦
Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
🇦🇷Hospital Pediatrico Dr Humberto J Notti, Mendoza, Argentina
🇦🇷Hospital de Niños Superiora Sor María Ludovica, La Plata, Buenos Aires, Argentina
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
- First Posted Date
- 2005-10-13
- Last Posted Date
- 2017-04-21
- Lead Sponsor
- OHSU Knight Cancer Institute
- Target Recruit Count
- 2
- Registration Number
- NCT00238173
- Locations
- 🇺🇸
OHSU Knight Cancer Institute, Portland, Oregon, United States
Antenatal Allopurinol During Fetal Hypoxia
- First Posted Date
- 2005-09-16
- Last Posted Date
- 2012-03-29
- Lead Sponsor
- UMC Utrecht
- Target Recruit Count
- 222
- Registration Number
- NCT00189007
- Locations
- 🇳🇱
UMCG, Groningen, Netherlands
🇳🇱Gelre hospitals, Apeldoorn, Netherlands
🇳🇱Jeroen Bosch Hospital, Den Bosch, Netherlands
Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients
- Conditions
- First Posted Date
- 2005-07-29
- Last Posted Date
- 2012-06-26
- Target Recruit Count
- 10
- Registration Number
- NCT00125229
- Locations
- 🇺🇸
Center for Neurosurgery Sciences - UTHSCSA - Surgical Intensive Care Unit (SICU), San Antonio, Texas, United States
Drug Development Updates
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