Mannitol

Generic Name: Mannitol

Brand Names: Aridol, Bronchitol, Cystosol, Osmitrol, Sag-M

Drug Type: Small Molecule

Chemical Formula: C_₆H_₁₄O_₆

CAS Number: 69-65-8

Unique Ingredient Identifier: 3OWL53L36A

Background: Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated i...

Indication: Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
...

Associated Conditions: Acute Renal Failure (ARF), Cystic Fibrosis (CF), Edema of the cerebrum, Increased Intra Ocular Pressure (IOP)

Associated Therapies: Bladder irrigation therapy

Clinical Trials

Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation

Phase 3

Completed

Conditions: Kidney Transplantation, Mannitol

Interventions: Drug: Mannitol

First Posted Date: 2016-03-10

Last Posted Date: 2018-11-07

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 34

Registration Number: NCT02705573

Locations: 🇦🇹
Medical University Vienna, Vienna, Austria

Evaluation of Ureteral Patency in the Post-indigo Carmine Era

Phase 4

Completed

Conditions: Ureteral Patency

Interventions: Other: Normal Saline
Drug: Sodium Fluorescein
Drug: Mannitol
Drug: Pyridium

First Posted Date: 2016-02-09

Last Posted Date: 2019-05-30

Lead Sponsor: Columbia University

Target Recruit Count: 140

Registration Number: NCT02677623

Locations: 🇺🇸
Columbia University Medical Center, New York, New York, United States

Asthma Exacerbations and Vascular Function

Not Applicable

Completed

Conditions: Asthma

Interventions: Drug: Mannitol
Drug: Methacholine
Drug: Placebo
Other: Rest
Other: Exercise

First Posted Date: 2015-12-15

Last Posted Date: 2021-07-01

Lead Sponsor: University of Alberta

Target Recruit Count: 52

Registration Number: NCT02630511

Locations: 🇨🇦
Clinical Physiology Research Laboratory, Edmonton, Alberta, Canada

Mannitol Versus Supportive Care in Ciguatera Fish Poisoning

Phase 3

Conditions: Ciguatoxin

Interventions: Drug: Mannitol

First Posted Date: 2015-10-07

Last Posted Date: 2015-10-07

Lead Sponsor: University of South Florida

Target Recruit Count: 200

Registration Number: NCT02570971

Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF

Not Applicable

Completed

Conditions: Acute Liver Failure

Interventions: Drug: 3% hypertonic saline
Drug: Mannitol

First Posted Date: 2015-06-02

Last Posted Date: 2016-02-17

Lead Sponsor: Institute of Liver and Biliary Sciences, India

Target Recruit Count: 52

Registration Number: NCT02460510

Locations: 🇮🇳
Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

A Study Comparing Picoprep With Mannitol and Bisacodyl for Colon Cleansing in Preparation for Colonoscopy

Phase 4

Completed

Conditions: Bowel Preparation

Interventions: Drug: sodium picosulfate, magnesium oxide and citric acid (Picoprep®)
Drug: mannitol
Drug: Bisacodyl

First Posted Date: 2015-03-12

Last Posted Date: 2016-01-12

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 184

Registration Number: NCT02386449

Locations: 🇧🇷
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (there may be other sites in this country), Sao Paulo, Brazil

The Leaky Lung Test

Early Phase 1

Completed

Conditions: Allergy
Asthma
Reactive Airway Disease
Lung Diseases, Obstructive

Interventions: Drug: Mannitol

First Posted Date: 2014-12-03

Last Posted Date: 2018-01-04

Lead Sponsor: University of Rochester

Target Recruit Count: 100

Registration Number: NCT02306473

Locations: 🇺🇸
University of Rochester Medical Center, Rochester, New York, United States

Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection

Not Applicable

Completed

Conditions: Intraocular Pressure Change in Intravitreal Injection

Interventions: Drug: Timolol
Drug: Brimonidine
Drug: Acetazolamide
Drug: Mannitol
Drug: Placebo

First Posted Date: 2014-05-16

Last Posted Date: 2014-05-16

Lead Sponsor: Mashhad University of Medical Sciences

Target Recruit Count: 70

Registration Number: NCT02140450

Locations: 🇮🇷
Retina Research Center, Khatam eye Hospital, Mashhad, Khorasan Razavi, Iran, Islamic Republic of

Mannitol Improves Cerebral Oxygen Saturation

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Control
Drug: Mannitol

First Posted Date: 2014-03-19

Last Posted Date: 2014-03-19

Lead Sponsor: Imam Abdulrahman Bin Faisal University

Target Recruit Count: 40

Registration Number: NCT02091180

Locations: 🇸🇦
King Fahd Hosital of the University, Al-Khobar, EP, Saudi Arabia
🇸🇦
Anesthesia Department, University of Dammam, Al-Khobar, EP, Saudi Arabia

Study of Stroke Related Edema Treatments

Phase 2

Withdrawn

Conditions: Acute Cerebrovascular Accident
Cerebral Edema

Interventions: Drug: Hypertonic saline
Drug: Conivaptan
Drug: Mannitol

First Posted Date: 2013-10-01

Last Posted Date: 2016-12-14

Lead Sponsor: University of Florida

Registration Number: NCT01954290

Drug Development Updates

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