Mannitol
- Generic Name
- Mannitol
- Brand Names
- Aridol, Bronchitol, Cystosol, Osmitrol, Sag-M
- Drug Type
- Small Molecule
- Chemical Formula
- C6H14O6
- CAS Number
- 69-65-8
- Unique Ingredient Identifier
- 3OWL53L36A
- Background
Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. As a result, cerebral edema, elevated i...
- Indication
Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
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- Associated Conditions
- Acute Renal Failure (ARF), Cystic Fibrosis (CF), Edema of the cerebrum, Increased Intra Ocular Pressure (IOP)
- Associated Therapies
- Bladder irrigation therapy
Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.
- Conditions
- Interventions
- First Posted Date
- 2020-09-01
- Last Posted Date
- 2020-11-12
- Lead Sponsor
- Bayer
- Target Recruit Count
- 50
- Registration Number
- NCT04534465
- Locations
- 🇺🇸
Merck Consumer Center, Memphis, Tennessee, United States
MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)
- Conditions
- Interventions
- First Posted Date
- 2020-06-11
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT04428372
- Locations
- 🇺🇸
Brigham and Women's, Boston, Massachusetts, United States
Effect of AD128 to Treat Obstructive Sleep Apnea
- First Posted Date
- 2020-05-19
- Last Posted Date
- 2021-08-06
- Lead Sponsor
- Raphael Heinzer
- Target Recruit Count
- 15
- Registration Number
- NCT04394143
- Locations
- 🇨🇭
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
#StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19
- First Posted Date
- 2020-05-12
- Last Posted Date
- 2021-05-11
- Lead Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
- Target Recruit Count
- 800
- Registration Number
- NCT04385264
- Locations
- 🇨🇭
Unisanté, Lausanne, Vaud, Switzerland
The Effect of Intravenous Mannitol Plus Saline on the Prevention of Cisplatin-induced Nephrotoxicity: A Randomized, Double-blind, Placebo Controlled Trial
- Conditions
- Interventions
- First Posted Date
- 2020-02-05
- Last Posted Date
- 2022-01-21
- Lead Sponsor
- Phramongkutklao College of Medicine and Hospital
- Target Recruit Count
- 48
- Registration Number
- NCT04251689
- Locations
- 🇹🇭
Phramongkutklao Hospital, Bangkok, Thailand
Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass
- Conditions
- Interventions
- First Posted Date
- 2020-01-03
- Last Posted Date
- 2024-05-16
- Lead Sponsor
- dr. M.J.N.L. Benders
- Target Recruit Count
- 236
- Registration Number
- NCT04217421
- Locations
- 🇳🇱
University Medical Center Groningen (UMCG), Groningen, Netherlands
🇳🇱Radboud University Medical Center Nijmegen (Radboudumc), Nijmegen, Netherlands
🇳🇱Erasmus Medical Center Rotterdam (Erasmus MC), Rotterdam, Netherlands
Effect of Intravenous Administration of Mannitol on ONSD in Patients With Raised ICP
- Conditions
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2019-12-16
- Target Recruit Count
- 40
- Registration Number
- NCT04188353
- Locations
- 🇳🇵
Maharajgunj Medical Campus, Kathmandu, Bagmati, Nepal
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2019-10-22
- Last Posted Date
- 2023-11-30
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 99
- Registration Number
- NCT04135456
- Locations
- 🇨🇳
Capital Medical University Affiliated Beijing Tiantan Hospital, Beijing, Beijing, China
Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation
- Conditions
- Interventions
- First Posted Date
- 2018-06-29
- Last Posted Date
- 2021-05-07
- Lead Sponsor
- Aristotle University Of Thessaloniki
- Target Recruit Count
- 54
- Registration Number
- NCT03573999
- Locations
- 🇬🇷
AHEPA University Hospital, Thessaloníki, Greece
🇬🇷Georgia Tsaousi, Thessaloníki, Greece
The Effect of Deep Inhalation on Mannitol Responsiveness
- Conditions
- Interventions
- First Posted Date
- 2018-04-23
- Last Posted Date
- 2019-05-15
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 26
- Registration Number
- NCT03505489
- Locations
- 🇨🇦
Asthma Research Lab - University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Drug Development Updates
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