Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Pain Relief After Hiatal Hernia Repair Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-06-23
- Last Posted Date
- 2021-06-23
- Lead Sponsor
- Norton Thoracic Institute
- Target Recruit Count
- 90
- Registration Number
- NCT04936711
- Locations
- 🇺🇸
St. Joseph's Hospital and Medical Center, Phoenix, Arizona, United States
Intrathecal Midazolam, Fentanyl and Nalbuphine as Adjuvants to Bupivacaine in Spinal Anesthesia for Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2021-06-18
- Last Posted Date
- 2022-04-05
- Lead Sponsor
- Benha University
- Target Recruit Count
- 100
- Registration Number
- NCT04932083
- Locations
- 🇪🇬
Samar Rafik Amin, Banhā, Qalubia, Egypt
Nebulized Bupivacaine Analgesia for Cleft Palate Repair
- Conditions
- Interventions
- First Posted Date
- 2021-06-16
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT04928352
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Assuit, Egypt
Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) in Major Abdominal Surgeries
- Conditions
- Interventions
- First Posted Date
- 2021-06-10
- Last Posted Date
- 2022-07-11
- Lead Sponsor
- Sameh Fathy
- Target Recruit Count
- 80
- Registration Number
- NCT04920994
- Locations
- 🇪🇬
Department of Anesthesia, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt
Ultrasound Guided Sacral Erector Spinae Plane Block in Pediatric Anorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2021-06-10
- Last Posted Date
- 2022-07-07
- Lead Sponsor
- Sameh Fathy
- Target Recruit Count
- 60
- Registration Number
- NCT04921007
- Locations
- 🇪🇬
Department of Anesthesia, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt
Exparel Use in Adductor Canal Block After Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2021-06-02
- Last Posted Date
- 2022-05-20
- Lead Sponsor
- St. Luke's Hospital, Pennsylvania
- Target Recruit Count
- 100
- Registration Number
- NCT04910165
- Locations
- 🇺🇸
St. Luke's University Health Network, Bethlehem, Pennsylvania, United States
POPLITEAL SCIATIC NERVE BLOCK FOR DIABETIC FOOT SURGERIES
- First Posted Date
- 2021-05-26
- Last Posted Date
- 2021-05-27
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 50
- Registration Number
- NCT04903743
- Locations
- 🇪🇬
rehab Abd Elaziz, Alexandria, Egypt
Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control
- Conditions
- Interventions
- First Posted Date
- 2021-05-24
- Last Posted Date
- 2023-10-30
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 60
- Registration Number
- NCT04897841
- Locations
- 🇺🇸
Unity-Point Health Meriter, Madison, Wisconsin, United States
Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections
- Conditions
- Interventions
- First Posted Date
- 2021-05-20
- Last Posted Date
- 2024-11-15
- Lead Sponsor
- Michael Khazzam
- Target Recruit Count
- 400
- Registration Number
- NCT04895280
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Video-assisted Thoracoscopic Surgery - Exparel Study
- Conditions
- Interventions
- First Posted Date
- 2021-04-28
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Nada Sadek
- Target Recruit Count
- 128
- Registration Number
- NCT04864210
- Locations
- 🇺🇸
University of Iowa, Iowa City, Iowa, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.