Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Erector Spinae Plane Block Versus Thoracic Epidural Block for Chest Trauma
- Conditions
- Interventions
- First Posted Date
- 2019-01-08
- Last Posted Date
- 2021-06-10
- Lead Sponsor
- Sameh Fathy
- Target Recruit Count
- 50
- Registration Number
- NCT03797079
- Locations
- 🇪🇬
Mansoura University Hospitals, Mansoura, Dakahlia, Egypt
Comparison of Two Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Cesarean Delivery
- First Posted Date
- 2019-01-04
- Last Posted Date
- 2021-09-24
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 110
- Registration Number
- NCT03792906
- Locations
- 🇪🇬
Ahmed Mohamed Hasanin, Cairo, Egypt
COMPARISON OF TRANSVERSUS ABDOMINIS PLANE BLOCK, LOCAL ANESTHETIC INJECTION TO THE PORT SITES AND INTRAPERITONEAL LOCAL ANESTHESIA APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS WITH LAPAROSCOPIC APPENDECTOMY
- First Posted Date
- 2018-12-31
- Last Posted Date
- 2021-03-23
- Target Recruit Count
- 3
- Registration Number
- NCT03790020
- Locations
- 🇹🇷
Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey
COMPARISON OF INTRAOPERATIVE LOCAL ANESTHETIC APPLICATIONS IN POSTOPERATIVE PAIN MANAGEMENT IN LAPAROSCOPIC CHOLECYSTECTOMY PATIENTS
- First Posted Date
- 2018-12-31
- Last Posted Date
- 2021-03-23
- Target Recruit Count
- 3
- Registration Number
- NCT03790007
- Locations
- 🇹🇷
Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey
Erector Spinae Plane Block for Peri-operative Pain Management in Pediatric Open Pyeloplasty Cases
- Conditions
- Interventions
- First Posted Date
- 2018-12-31
- Last Posted Date
- 2019-02-26
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 40
- Registration Number
- NCT03790566
- Locations
- 🇹🇷
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Please Select, Turkey
Study in Subjects Undergoing Complete Abdominoplasty
- First Posted Date
- 2018-12-28
- Last Posted Date
- 2024-03-19
- Lead Sponsor
- Concentric Analgesics
- Target Recruit Count
- 54
- Registration Number
- NCT03789318
- Locations
- 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States
Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI)
- Conditions
- Interventions
- First Posted Date
- 2018-12-26
- Last Posted Date
- 2021-01-14
- Lead Sponsor
- Albert Einstein College of Medicine
- Registration Number
- NCT03787147
Comparing Analgesic Effects of Three Ultrasound Guided Regional Anesthetic Techniques in Pediatrics
- First Posted Date
- 2018-12-19
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 135
- Registration Number
- NCT03780790
- Locations
- 🇹🇷
Istanbul University, Istanbul, Turkey
ED90 for Hyperbaric Bupivacaine in Super Obese Parturients
- Conditions
- Interventions
- First Posted Date
- 2018-12-19
- Last Posted Date
- 2023-02-02
- Lead Sponsor
- Duke University
- Target Recruit Count
- 45
- Registration Number
- NCT03781388
- Locations
- 🇺🇸
Duke University Hospital, Durham, North Carolina, United States
Role of Dexamethasone for Erector Spinae Plane Block in Patients Undergoing Total Abdominal Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2018-12-10
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT03769818
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.