Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Para-vertebral Dexmedetomidine and the Incidence of Postoperative Chronic Pain

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Dexmedetomidine
Drug: Bupivacaine

First Posted Date: 2018-08-15

Last Posted Date: 2018-08-21

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT03632161

Locations: 🇪🇬
Emad Zarief Kamel Said, Assiut, Egypt

US-guided SAPB for Rib Fractures in the ED

Phase 4

Conditions: Rib Fractures
Rib Fracture Multiple

Interventions: Drug: Fentanyl, morphine, hydromorphone, hydrocodone, acetaminophen, ketorolac, gabapentin, ketamine, ibuprofen
Drug: Bupivacaine

First Posted Date: 2018-08-08

Last Posted Date: 2018-12-19

Lead Sponsor: Andrew A Herring

Target Recruit Count: 70

Registration Number: NCT03619785

Locations: 🇺🇸
Alameda Health System - Highland Hospital, Oakland, California, United States

Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-prostatectomy Analgesia

Not Applicable

Terminated

Conditions: Prostatic Cancer
Pain, Postoperative
Pain
Anesthetics, Local

Interventions: Diagnostic Test: Quadratus Lumborum block
Diagnostic Test: Tranversus Abdominis plane block
Drug: Bupivacaine

First Posted Date: 2018-07-31

Last Posted Date: 2022-06-06

Lead Sponsor: Jagiellonian University

Target Recruit Count: 12

Registration Number: NCT03606889

Locations: 🇵🇱
University Hospital in Cracow, Kraków, Poland

Postoperative Analgesia of Magnesium Sulfate in Suprascapular Nerve Block Following Shoulder Arthroscopy

Not Applicable

Conditions: Arthroscopic Shoulder Surgery

Interventions: Drug: Bupivacaine-magnesium
Drug: Bupivacaine
Drug: Propofol
Device: Ultrasound
Drug: Sevoflurane
Drug: Rocuronium

First Posted Date: 2018-07-26

Last Posted Date: 2018-07-26

Lead Sponsor: Mansoura University

Target Recruit Count: 60

Registration Number: NCT03602469

Locations: 🇪🇬
Mansoura University, Mansourah, DK, Egypt

Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients

Phase 2

Completed

Conditions: Post-surgical Pain

Interventions: Drug: CA-008
Drug: Placebo
Drug: Ketorolac
Drug: Acetaminophen
Drug: Oxycodone
Drug: Bupivacaine Hydrochloride

First Posted Date: 2018-07-26

Last Posted Date: 2021-08-11

Lead Sponsor: Concentric Analgesics

Target Recruit Count: 147

Registration Number: NCT03599089

Locations: 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States
🇺🇸
Chesapeake Research Group, Pasadena, Maryland, United States
🇺🇸
HD Research Corp, Houston, Texas, United States