MedPath

Bupivacaine

Generic Name
Bupivacaine
Brand Names
Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
Drug Type
Small Molecule
Chemical Formula
C18H28N2O
CAS Number
38396-39-3
Unique Ingredient Identifier
Y8335394RO
Background

Bupivacaine is a widely used local anesthetic agent.

Indication

As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions
Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
Associated Therapies
General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Clinical Trials
Related News

Dexmedetomidine Versus Fentanyl Plus Bupivacaine for Epidural Analgesia With General Anesthesia for Lumbar Disc Operations

Phase 4
Completed
Conditions
Anesthesia
Interventions
Drug: Bupivacaine
Drug: Fentanyl
Drug: Dexmedetomidine
First Posted Date
2018-02-19
Last Posted Date
2018-09-27
Lead Sponsor
Ain Shams University
Target Recruit Count
80
Registration Number
NCT03438240
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Study in Adult Subjects Undergoing Posterolateral Thoracotomy

Phase 1
Terminated
Conditions
Postoperative Pain Management
Interventions
Drug: EXPAREL
First Posted Date
2018-02-12
Last Posted Date
2019-02-06
Lead Sponsor
Pacira Pharmaceuticals, Inc
Target Recruit Count
5
Registration Number
NCT03428984
Locations
🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

Ultrasound-Guided Versus Conventional Method for Caudal Block

Not Applicable
Completed
Conditions
Ultrasound Therapy; Complications
Interventions
Drug: Bupivacaine
Drug: Adrenalin
Device: Ultrasound
First Posted Date
2018-02-09
Last Posted Date
2018-02-09
Lead Sponsor
Omer Karaca
Target Recruit Count
275
Registration Number
NCT03427437
Locations
🇹🇷

Baskent University, Konya, Turkey

Suprazygomatic Block in Cleft Palate Surgery in Children

Phase 2
Completed
Conditions
Cleft Palate
Interventions
Drug: Bupivacaine
Drug: Dexmedetomidine
Drug: paracetamol
First Posted Date
2018-01-26
Last Posted Date
2018-09-24
Lead Sponsor
Assiut University
Target Recruit Count
80
Registration Number
NCT03412474
Locations
🇪🇬

Assiut University Hospital, Assiut, Egypt

Safety and Efficacy of Addition of Hyaluronidase to Lidocaine and Bupivacaine in Scalp Nerves Block in Elective Craniotomy Operations, Comparative Study

Early Phase 1
Completed
Conditions
Addition of Hyalase to Local Anesthetic in Scalp Block
Interventions
Drug: Hyaluronidase
Drug: Lidocaine
Drug: Bupivacaine
First Posted Date
2018-01-26
Last Posted Date
2018-04-27
Lead Sponsor
Cairo University
Target Recruit Count
64
Registration Number
NCT03411330
Locations
🇪🇬

Ahmed Abdalla Mohamed, Cairo, Egypt

Bupivacaine Versus Liposomal Bupivacaine For Breast Pain Management After Breast Recontruction

Phase 2
Withdrawn
Conditions
Breast Cancer
Interventions
Drug: Liposomal Bupivacaine
Drug: Bupivacaine
Drug: Patient-Controlled Analgesia Pump
Drug: Oral Narcotic
First Posted Date
2018-01-08
Last Posted Date
2020-07-22
Lead Sponsor
Case Comprehensive Cancer Center
Registration Number
NCT03393117

Laparoscopic Guided Transversus Abdominis Plane Block for Postoperative Analgesia After Pediatric Laparoscopic Surgery.

Phase 2
Conditions
Analgesia
Interventions
Procedure: TAB Block
Procedure: Psoas Block
Drug: Bupivacaine
First Posted Date
2018-01-03
Last Posted Date
2020-07-14
Lead Sponsor
Assiut University
Target Recruit Count
44
Registration Number
NCT03388671
Locations
🇪🇬

Pediatric hospital, faculty of medicine, Assiut university, Assiut, Assiut Governorate, Egypt

Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section

Phase 2
Terminated
Conditions
Pain, Referred
Interventions
Drug: Bupivacaine
Drug: Morphine
Drug: Fentanyl
Drug: Epinephrine
Other: Saline solution
First Posted Date
2017-12-26
Last Posted Date
2020-01-13
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
26
Registration Number
NCT03383588
Locations
🇺🇸

Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, New York, United States

Post C-Section Pain Control Using EXPAREL

Phase 4
Withdrawn
Conditions
Pain, Postoperative
Interventions
Drug: Exparel
First Posted Date
2017-12-19
Last Posted Date
2021-05-18
Lead Sponsor
University of Minnesota
Registration Number
NCT03377595
Locations
🇺🇸

University of Minnesota, Minneapolis, Minnesota, United States

Fascia Iliaca Blocks for Pain Control After Total Hip Arthroplasty

Phase 4
Completed
Conditions
Arthritis of Hip
Interventions
Procedure: Fascia iliaca compartment block
Drug: Placebo
Drug: Bupivacaine
First Posted Date
2017-12-15
Last Posted Date
2023-10-10
Lead Sponsor
Henry Ford Health System
Target Recruit Count
122
Registration Number
NCT03375112
Locations
🇺🇸

Henry Ford Hospital, Detroit, Michigan, United States

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