Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Comparative Efficacy & Safety of Dexmedetomidine vs Tramadol in Paeds Hernioraphy. A Caudal Anaesthesia Approach
- Conditions
- Hemodynamic StabilityPost Operative PainInguinal Hernia Repair
- Interventions
- First Posted Date
- 2024-12-16
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Sahiwal medical college sahiwal
- Target Recruit Count
- 60
- Registration Number
- NCT06735443
- Locations
- 🇵🇰
Sahiwal Medical College Sahiwal, Sahiwal, Punjab, Pakistan
Comparative Study Between the Analgesic Effect of Dexmedetomidine and Magnesium Sulfate As Adjuvant to Bupivacaine Using Ultrasound-Guided Transversus Abdominis Plane Block in Abdominal Hysterectomy : a Randomized Double-blinded Study
- Conditions
- Hysterectomy
- Interventions
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 64
- Registration Number
- NCT06720337
Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use
- Conditions
- HysterectomyPost Operative Analgesia
- Interventions
- Other: Saline (NaCl 0,9 %) (placebo)
- First Posted Date
- 2024-12-05
- Last Posted Date
- 2025-01-07
- Lead Sponsor
- MediSys Health Network
- Target Recruit Count
- 100
- Registration Number
- NCT06719180
- Locations
- 🇺🇸
Flushing Hospital Medical Center, Flushing, New York, United States
Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery
- Conditions
- Pain SyndromeDizzinessVomitingItchingSweet SyndromeColdSatisfaction, Patient
- Interventions
- First Posted Date
- 2024-11-26
- Last Posted Date
- 2024-12-30
- Lead Sponsor
- Zhejiang Cancer Hospital
- Target Recruit Count
- 132
- Registration Number
- NCT06704698
- Locations
- 🇨🇳
Jiangling Wang, Hangzhou, Zhejiang, China
Liposomal Bupivacaine for Postoperative Pain After Craniotomy
- Conditions
- Liposome Bupivacaine
- Interventions
- First Posted Date
- 2024-11-22
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 106
- Registration Number
- NCT06701539
Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients
- Conditions
- Peripheral Arterial DiseaseSubarachnoid BlockFemoropopliteal BlockTissue Oxygen Saturation
- Interventions
- Drug: Mixture of local anesthetics
- First Posted Date
- 2024-11-22
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Indonesia University
- Target Recruit Count
- 16
- Registration Number
- NCT06702202
- Locations
- 🇮🇩
Cipto Mangunkusumo Cental National Hospital, Jakarta, DKI Jakarta, Indonesia
Suprazygomatic Maxillary Nerve Block for Management of Postoperative Pain in Adenotonsillectomy Patients
- Conditions
- Tonsillectomy Postoperative Adverse EventsDexamethasone AdministrationBupivacaine
- Interventions
- First Posted Date
- 2024-11-19
- Last Posted Date
- 2024-11-19
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT06694077
Comparison Between Clavipectoral Fascia Block & Interscalene Brachial Plexus Block As Regard Adequacy of Anesthesia in Clavicle Surgeries
- Conditions
- Clavicle Fracture
- Interventions
- First Posted Date
- 2024-11-18
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 42
- Registration Number
- NCT06692010
Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl As Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries
- Conditions
- Magnesium SulfateNeostigmineFentanyl
- Interventions
- Drug: Magnesium Sulfate and Bupivacaine 0.125%
- First Posted Date
- 2024-11-12
- Last Posted Date
- 2024-11-12
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 66
- Registration Number
- NCT06685705
Effect of Adding Magnesium Sulphate As Adjuvant to Bupivacaine in Ultrasound Guided External Oblique Intercostal Plane Block in Upper Abdominal Cancer Surgery.to Assess the Total Postoperative Opioid Consumption in the First 24 H and Evaluate Post Operative VAS Score
- Conditions
- Upper Abdominal Cancer Surgery
- Interventions
- Drug: Magnesium Sulfate and Bupivacaine 0.125%
- First Posted Date
- 2024-11-07
- Last Posted Date
- 2024-11-07
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 68
- Registration Number
- NCT06677827
Drug Development Updates
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