Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Continuous Versus Single-Shot Spinal Anesthesia for Orthopedic Surgery

Not Applicable

Recruiting

Conditions: Post Operative Pain

Interventions: Drug: Bupivacaine 0.5% Injectable Solution
Drug: Isoflurane Inhalant Product

First Posted Date: 2024-10-03

Last Posted Date: 2024-10-28

Lead Sponsor: Benha University

Target Recruit Count: 105

Registration Number: NCT06625606

Locations: 🇪🇬
Benha University, Banhā, El Qalyoubia, Egypt

EXPAREL IPSA Block in Knee Arthroplasty

Phase 4

Conditions: Pain, Postoperative
Osteo Arthritis Knee

Interventions: Drug: Exparel

First Posted Date: 2024-09-30

Last Posted Date: 2024-09-30

Lead Sponsor: Campbell Clinic

Target Recruit Count: 10

Registration Number: NCT06619340

Locations: 🇺🇸
Campbell Clinic, Germantown, Tennessee, United States

The Effect of Intraperitoneal Instillation of Bupivacaine on Postoperative Pain After Surgical Laparoscopy

Phase 3

Completed

Conditions: Post Operative Pain

Interventions: Drug: Bupivacaine

First Posted Date: 2024-09-27

Last Posted Date: 2024-09-27

Lead Sponsor: El Shatby University Hospital for Obstetrics and Gynecology

Target Recruit Count: 80

Registration Number: NCT06616441

Locations: 🇪🇬
Faculty of Medicine, University of Alexandria, Alexandria, Egypt

Pain Palliation in Forearm Fractures in the Emergency Department

Not Applicable

Completed

Conditions: Forearm Fracture
Radius Fractures
Ulnar Fracture

Interventions: Drug: Ketamine
Drug: Bupivacaine Hydrochloride

First Posted Date: 2024-09-19

Last Posted Date: 2024-12-27

Lead Sponsor: Ankara Etlik City Hospital

Target Recruit Count: 85

Registration Number: NCT06588907

Locations: 🇹🇷
Ankara Etlik City Hospital, Ankara, Yenimahalle, Turkey

Spinal Anesthesia by Hyperbaric Prilocaine in Day-Case Perianal Surgery

Not Applicable

Completed

Conditions: Spinal Anesthesia
Hyperbaric
Prilocaine
Day-Case
Perianal Surgery

Interventions: Drug: Hyperbaric prilocaine
Drug: Hyperbaric bupivacaine

First Posted Date: 2024-09-19

Last Posted Date: 2025-03-27

Lead Sponsor: Tanta University

Target Recruit Count: 90

Registration Number: NCT06600048

Locations: 🇪🇬
Tanta University, Tanta, El-Gharbia, Egypt

Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis

Phase 4

Recruiting

Conditions: Endometriosis

Interventions: Drug: Normal saline
Drug: Bupivacaine Hydrochloride

First Posted Date: 2024-08-29

Last Posted Date: 2024-08-29

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 60

Registration Number: NCT06577233

Locations: 🇺🇸
Texas Childrens Hospital Pavilion for Women, Houston, Texas, United States

Rectus Sheath Block for Analgesia After Gynecological Laparotomy

Phase 4

Recruiting

Conditions: Gynecologic Surgical Procedures

Interventions: Procedure: Rectus sheath block
Procedure: Thoracic Epidural Analgesia
Drug: Liposomal bupivacaine
Drug: Bupivacaine-Hydromorphone Cassette
Drug: Bupivacaine Hydrochloride

First Posted Date: 2024-08-28

Last Posted Date: 2024-10-17

Lead Sponsor: Duke University

Target Recruit Count: 90

Registration Number: NCT06575699

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Exparel v Dexamethasone in RCR

Phase 4

Conditions: Rotator Cuff Tears
Postoperative Pain

Interventions: Drug: Liposomal bupivacaine
Drug: Bupivacaine Hcl 0.5% Inj
Drug: Dexamethasone

First Posted Date: 2024-08-28

Last Posted Date: 2024-08-28

Lead Sponsor: Rothman Institute Orthopaedics

Target Recruit Count: 126

Registration Number: NCT06575010

Locations: 🇺🇸
Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States

Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks

Phase 4

Not yet recruiting

Conditions: Mastectomy; Lymphedema
Breast Cancer

Interventions: Drug: Bupivacain
Procedure: Intraoperative Pecs II block (IOB) & superior AT (EX or BP)
Procedure: Preoperative Pecs II block (POB) & superior AT (EX or BP)
Drug: Exparel