Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
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Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Comparing Heavy Levobupivacaine With Enantiomeric Excess of 50% and Heavy Racemic Bupivacaine.

Phase 3

Withdrawn

Conditions: Fracture of Lower Limb

Interventions: Drug: Bupivacaine

First Posted Date: 2011-03-03

Last Posted Date: 2014-03-26

Lead Sponsor: Cristália Produtos Químicos Farmacêuticos Ltda.

Registration Number: NCT01308047

Locations: 🇧🇷
Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil
🇧🇷
Hospital Sepaco, São Paulo, Brazil

Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Bupivacaine
Procedure: Injection

First Posted Date: 2011-03-01

Last Posted Date: 2013-04-11

Lead Sponsor: Bispebjerg Hospital

Target Recruit Count: 10

Registration Number: NCT01305603

Locations: 🇩🇰
Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, Capital Region of Denmark, Denmark

Comparison of Standard and Minidose Spinal Anesthesia for Cesarean Section Operation Using Marcaine Spinal 0.5% Heavy

Phase 4

Conditions: Cesarean Section
Anesthesia, Spinal
Local Anaesthetics Causing Adverse Effects in Therapeutic Use

Interventions: Drug: Bupivacaine
Drug: Bupivacaine and Fentanyl

First Posted Date: 2011-02-25

Last Posted Date: 2011-02-25

Lead Sponsor: Bnai Zion Medical Center

Target Recruit Count: 100

Registration Number: NCT01303731

Locations: 🇮🇱
Bnai Zion Medical Center, Haifa, Israel

Comparative Mixture of Non-racemic and Racemic Enantiomers of Bupivacaine in Cesarean

Phase 3

Withdrawn

Conditions: Cesarean Delivery

Interventions: Drug: Bupivacaine

First Posted Date: 2011-02-24

Last Posted Date: 2014-03-26

Lead Sponsor: Cristália Produtos Químicos Farmacêuticos Ltda.

Registration Number: NCT01303107

Locations: 🇧🇷
Irmandade da Santa Casa da Misericórdia de Santos, Santos, São Paulo, Brazil
🇧🇷
Irmandade da Santa Casa de Misericóridia de São Paulo, São Paulo, Brazil