Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
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Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery

Not Applicable

Completed

Conditions: Postoperative Pain
Wisdom Tooth

Interventions: Drug: ibuprofen
Drug: Brufen retard
Drug: Bupivacaine

First Posted Date: 2009-05-08

Last Posted Date: 2009-06-01

Lead Sponsor: University of Manchester

Target Recruit Count: 122

Registration Number: NCT00895843

Locations: 🇬🇧
Central Manchester and Manchester Children's NHS University Hospitals, Manchester, Lancashire, United Kingdom
🇬🇧
Central Manchester NHS Foundation Trust, Manchester, Lancashire, United Kingdom

Epidural Study of Patients With Chronic Lower Back Pain

Not Applicable

Completed

Conditions: Chronic Low Back Pain

Interventions: Drug: Bupivacaine
Drug: Depo-Medrol

First Posted Date: 2009-04-23

Last Posted Date: 2012-02-08

Lead Sponsor: Hamilton Health Sciences Corporation

Target Recruit Count: 252

Registration Number: NCT00887003

Locations: 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada

Stellate Ganglion Nerve Block in Treating Women With Hot Flashes

Early Phase 1

Completed

Conditions: Hot Flashes

First Posted Date: 2009-04-09

Last Posted Date: 2014-10-17

Lead Sponsor: Mayo Clinic

Target Recruit Count: 10

Registration Number: NCT00879164

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

A Comparison of Bupivacaine and 2-chloroprocaine for Spinal Anesthesia

Not Applicable

Completed

Conditions: Spinal Anesthesia

Interventions: Drug: chloroprocaine
Drug: bupivacaine

First Posted Date: 2009-02-18

Last Posted Date: 2010-01-27

Lead Sponsor: Université de Montréal

Target Recruit Count: 106

Registration Number: NCT00845962

Locations: 🇨🇦
St-Luc Hospital CHUM, Montreal, Quebec, Canada

Perioperative Analgesia Using Ultrasound (US) Guided Transversus Abdominis Plane (TAP) Block

Early Phase 1

Conditions: Postoperative Pain

Interventions: Drug: Bupivacaine
Other: TAP

First Posted Date: 2009-01-09

Last Posted Date: 2015-09-15

Lead Sponsor: King Saud University

Target Recruit Count: 42

Registration Number: NCT00819962

Locations: 🇸🇦
A Dawlatly, Riyadh, Saudi Arabia

Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation

Phase 3

Terminated

Conditions: Pain

Interventions: Drug: SKY0402
Drug: Bupivacaine HCl

First Posted Date: 2008-12-22

Last Posted Date: 2014-01-16

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 136

Registration Number: NCT00813111

Locations: 🇺🇸
Miami Plastic Surgery, Miami, Florida, United States
🇺🇸
The Ohio State University Research Foundation, Columbus, Ohio, United States
🇺🇸
West Alabama Research, LLC., Birmingham, Alabama, United States

and more 12 locations