Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
The PAIN (Pelvic Area Injection for Numbness) Study
- Conditions
- Vaginal Laceration During Delivery
- Interventions
- First Posted Date
- 2023-08-02
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT05972681
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Comparison of Local Anesthetic Dose in Ipack Block Performed in Knee Arthroplasty Operations
- Conditions
- AnalgesiaPain, PostoperativeAnesthesia
- Interventions
- First Posted Date
- 2023-07-27
- Last Posted Date
- 2024-02-13
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 112
- Registration Number
- NCT05963139
- Locations
- 🇹🇷
Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
Comparison Between Bupivacaine and Bupivacaine- Dexamethasone QLB for Postoperative Analgesia
- First Posted Date
- 2023-06-26
- Last Posted Date
- 2023-08-24
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT05918796
- Locations
- 🇪🇬
Ain Shams University Hospital, Cairo, EL Abassia, Egypt
Effects on Postoperative Pain of Liposomal Bupivacaine in Interscalene Blocks for Total Shoulder Arthroplasty Patients
- Conditions
- Total Shoulder ArthroplastyReverse Total Shoulder Arthroplasty
- Interventions
- First Posted Date
- 2023-06-12
- Last Posted Date
- 2023-09-13
- Lead Sponsor
- Johnny K. Lee
- Target Recruit Count
- 120
- Registration Number
- NCT05900427
- Locations
- 🇺🇸
NorthShore University HealthSystem, Skokie, Illinois, United States
A Study of Liposomal Bupivacaine Versus 0.25% Bupivacaine Hydrochloride Post Breast Reduction
- Conditions
- Breast Reduction
- Interventions
- First Posted Date
- 2023-06-07
- Last Posted Date
- 2024-04-17
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 42
- Registration Number
- NCT05891613
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
Comparing the Hemodynamic Effects of Epinephrine Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Caudal Anaesthesia Assessed by Cardiometry
- Conditions
- Anesthesia, Local
- Interventions
- First Posted Date
- 2023-05-16
- Last Posted Date
- 2023-05-16
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 39
- Registration Number
- NCT05860010
- Locations
- 🇪🇬
Kasr Al Ainy, Cairo, Egypt
🇪🇬Ayman Abougabal [aabougabal], Cairo, Egypt
Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain
- Conditions
- Analgesia
- Interventions
- First Posted Date
- 2023-05-10
- Last Posted Date
- 2024-02-20
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 60
- Registration Number
- NCT05851768
- Locations
- 🇪🇬
Walaa Y Elsabeeny, Cairo, Egypt
Bupivacaine Versus Bupivacaine Plus Lidocaine in Infraclavicular Block
- Conditions
- Pain, AcuteAnalgesiaPostoperative Pain
- Interventions
- Drug: Bupivacaine-LidocaineDrug: Bupivacaine
- First Posted Date
- 2023-04-27
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- Hospital de San Carlos Dr. Benicio Arzola Medina
- Target Recruit Count
- 40
- Registration Number
- NCT05834023
- Locations
- 🇨🇱
Hospital de San Carlos Dr. Benicio Arzola Medina, San Carlos, Ñuble, Chile
Clonidine for Infra-orbital Nerve Block During Pediatric Cleft Lip Revision Surgeries
- Conditions
- Postoperative Pain
- Interventions
- First Posted Date
- 2023-03-29
- Last Posted Date
- 2023-08-22
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 86
- Registration Number
- NCT05790044
Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
- Conditions
- Analgesia
- Interventions
- Drug: BupivacaineDrug: Bupivacaine-Neostigmine
- First Posted Date
- 2023-03-27
- Last Posted Date
- 2024-02-06
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 58
- Registration Number
- NCT05785377
- Locations
- 🇪🇬
Mansoura University-Emergency hospital-ICU, El Mansoura, Mansoura, Egypt
Drug Development Updates
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