Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae
- Conditions
- Postpartum Perineal PainEpisiotomyVaginal DeliveryPrimigravidaeBupivacaineLignocaine
- Interventions
- First Posted Date
- 2024-08-23
- Last Posted Date
- 2024-08-23
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06568289
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
- Conditions
- Medial Patellofemoral Ligament (MPFL) ReconstructionSports Injuries in ChildrenAnalgesiaPain, Postoperative
- Interventions
- First Posted Date
- 2024-08-19
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- Texas Scottish Rite Hospital for Children
- Target Recruit Count
- 100
- Registration Number
- NCT06559215
- Locations
- 🇺🇸
Texas Scottish Rite Hospital for Children, Frisco, Texas, United States
Comparison of Intraperitoneal Bupivacaine Alone or With Dexmedetomidine
- Conditions
- LAPAROSCOPIC CHOLECYSTECTOMY
- Interventions
- First Posted Date
- 2024-08-19
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- RESnTEC, Institute of Research
- Target Recruit Count
- 68
- Registration Number
- NCT06560892
- Locations
- 🇵🇰
Quaid-e-Azam Medical College, Bahawalpur, Punjab, Pakistan
Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty
- Conditions
- Osteoarthritis, Knee
- Interventions
- Drug: traditional peri-articular injection
- First Posted Date
- 2024-08-16
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- Dezhou Hospital Qilu Hospital of Shandong University
- Target Recruit Count
- 60
- Registration Number
- NCT06557018
- Locations
- 🇨🇳
Qilu Hospital of Shandong University Dezhou Hospital (Dezhou People's Hospital), Dezhou, Shandong, China
Dexmedetomidine As An Adjuvant To Bupivacaine 0.1% in Labor Analgesia
- Conditions
- Labor AnalgesiaLabor Pain
- Interventions
- First Posted Date
- 2024-08-13
- Last Posted Date
- 2024-08-13
- Lead Sponsor
- Services Institute of Medical Sciences, Pakistan
- Target Recruit Count
- 165
- Registration Number
- NCT06550414
- Locations
- 🇵🇰
Hameed Lateef Hospital, Lahore, Punjab, Pakistan
Exparel Versus Bupivacaine in Post-operative Pain Control
- Conditions
- Liposomal Bupivacaine
- Interventions
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2025-02-13
- Lead Sponsor
- Case Western Reserve University
- Target Recruit Count
- 100
- Registration Number
- NCT06547255
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
The Difference Between Using Local and General Dexamethasone in Arthroscopic Anterior Cruciate Ligament Repair
- Conditions
- ACL Injury
- Interventions
- First Posted Date
- 2024-08-05
- Last Posted Date
- 2024-08-05
- Lead Sponsor
- Benha University
- Target Recruit Count
- 123
- Registration Number
- NCT06537518
- Locations
- 🇪🇬
Benha faculty of Medicine, Banhā, El Qalyoubia, Egypt
Compare Intraperitoneal Instillation of Bupivacaine+dexmedetomidine Versus Bupivacaine+dexamethasone on Postoperative Pain After Lap Cholecystectomy
- Conditions
- Postoperative Pain
- Interventions
- First Posted Date
- 2024-08-02
- Last Posted Date
- 2025-03-11
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT06535256
- Locations
- 🇪🇬
Zaher, Cairo, Egypt
🇪🇬Zaher, Cairo, Egypt
Postoperative Analgesic Effectiveness of Bupivacaine With and Without Dexmedetomidine in Patients With Abdominal Surgery
- Conditions
- HypotensionVomitingPost Operative PainNauseaBradycardia
- Interventions
- First Posted Date
- 2024-08-01
- Last Posted Date
- 2024-08-01
- Lead Sponsor
- Sahiwal medical college sahiwal
- Target Recruit Count
- 64
- Registration Number
- NCT06531603
- Locations
- 🇵🇰
Sahiwal Medical College, Sahiwal, Punjab, Pakistan
A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery
- Conditions
- Local Analgesia Via Nerve Block
- Interventions
- First Posted Date
- 2024-07-31
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 96
- Registration Number
- NCT06529432
- Locations
- 🇨🇳
Zhongshan Hospital Affiliated to Fudan University, Shanghai, Shanghai, China
Drug Development Updates
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