Cefazolin
- Generic Name
- Cefazolin
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14N8O4S3
- CAS Number
- 25953-19-9
- Unique Ingredient Identifier
- IHS69L0Y4T
- Background
A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
- Indication
Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
- Associated Conditions
- Bacterial Septicemia caused by susceptible Bacterial Infections, Biliary tract infection bacterial caused by susceptible Bacterial Infections, Bone and Joint Infections caused by susceptible Bacterial Infections, Catheter-related Bloodstream Infection (CRBSI) NOS, Community Acquired Pneumonia (CAP), Endocarditis caused by susceptible Bacterial Infections, Genital infection caused by susceptible Bacterial Infections, Osteoarticular Infections, Postoperative Infections, Respiratory Tract Infection Bacterial caused by susceptible Bacterial Infections, Skin and Soft Tissue Infections (SSTIs), Skin and Subcutaneous Tissue Infection caused by susceptible Bacterial Infections, Susceptible infections, Urinary Tract Infection caused by susceptible Bacterial Infections, Perioperative infection, Susceptible Bacterial Infections
- Associated Therapies
- Antibiotic pre-surgical prophylaxis
Tinidazole Versus Cefazolin Antibiotic Prophylaxis of Vaginal and Abdominal Hysterectomy
- Conditions
- Hysterectomy
- Interventions
- First Posted Date
- 2008-11-07
- Last Posted Date
- 2008-11-07
- Lead Sponsor
- University of Campinas, Brazil
- Target Recruit Count
- 75
- Registration Number
- NCT00787553
- Locations
- 🇧🇷
University of Campinas, Campinas, SP, Brazil
Prophylactic Antibiotic Use in Hernioplasty
- Conditions
- Inguinal Hernia
- First Posted Date
- 2008-03-17
- Last Posted Date
- 2012-02-07
- Lead Sponsor
- Nihon University
- Target Recruit Count
- 400
- Registration Number
- NCT00636831
- Locations
- 🇯🇵
Nihon University School of Medicine, Department of Surgery, Tokyo, Japan
Antibiotic Prophylaxis in Orthopaedic Traumatology
- Conditions
- Fractures, ClosedWounds and Injuries
- Interventions
- Drug: Placebo
- First Posted Date
- 2008-02-08
- Last Posted Date
- 2015-06-12
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 178
- Registration Number
- NCT00610987
- Locations
- 🇺🇸
University of Missouri, Columbia, Missouri, United States
Prophylactic Antibiotics for Prevention of Wound Complications Following Vulvectomy
- Conditions
- Wound Infection
- Interventions
- First Posted Date
- 2007-10-29
- Last Posted Date
- 2018-10-17
- Lead Sponsor
- Aultman Health Foundation
- Target Recruit Count
- 18
- Registration Number
- NCT00550290
- Locations
- 🇺🇸
Aultman Health Foundation, Canton, Ohio, United States
Comparison of 2 Cefazolin Prophylactic Protocol in Laryngectomy Patients
- Conditions
- Laryngeal Cancer
- First Posted Date
- 2007-05-01
- Last Posted Date
- 2007-05-01
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT00467948
- Locations
- 🇮🇷
Imam khomaini hospital, Tehran, Iran, Islamic Republic of
Timing of Prophylactic Antibiotics for Cesarean Sections
- Conditions
- Wound InfectionEndometritis
- First Posted Date
- 2006-05-26
- Last Posted Date
- 2007-09-27
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 350
- Registration Number
- NCT00330278
- Locations
- 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
Oral Moxifloxacin Versus Cefazolin and Oral Probenecid in the Management of Skin and Soft Tissue Infections in the Emergency Department
- Conditions
- Cellulitis
- First Posted Date
- 2006-05-09
- Last Posted Date
- 2012-02-08
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 390
- Registration Number
- NCT00323219
- Locations
- 🇨🇦
St. Paul's Hospital, Providence Healthcare, Emergency Medicine, Vancouver, British Columbia, Canada
Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections
- Conditions
- BacteremiaGram-Positive Bacterial Infections
- First Posted Date
- 2005-04-18
- Last Posted Date
- 2012-08-07
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 61
- Registration Number
- NCT00108433
- Locations
- 🇸🇰
Pfizer Investigational Site, Nitra, Slovakia
Drug Development Updates
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