Cefazolin

Generic Name: Cefazolin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₄N_₈O_₄S_₃

CAS Number: 25953-19-9

Unique Ingredient Identifier: IHS69L0Y4T

Background: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Indication: Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylax...

Associated Conditions: Bacterial Septicemia caused by susceptible Bacterial Infections, Biliary tract infection bacterial caused by susceptible Bacterial Infections, Bone and Joint Infections caused by susceptible Bacterial Infections, Catheter-related Bloodstream Infection (CRBSI) NOS, Community Acquired Pneumonia (CAP), Endocarditis caused by susceptible Bacterial Infections, Genital infection caused by susceptible Bacterial Infections, Osteoarticular Infections, Postoperative Infections, Respiratory Tract Infection Bacterial caused by susceptible Bacterial Infections, Skin and Soft Tissue Infections (SSTIs), Skin and Subcutaneous Tissue Infection caused by susceptible Bacterial Infections, Susceptible infections, Urinary Tract Infection caused by susceptible Bacterial Infections, Perioperative infection, Susceptible Bacterial Infections

Associated Therapies: Antibiotic pre-surgical prophylaxis

Clinical Trials

Prophylactic Antibiotic in Treatment of Fingertip Amputation

Not Applicable

Completed

Conditions: Infection Rate After Fingertip Amputation

Interventions: Drug: Cephazolin

First Posted Date: 2014-03-04

Last Posted Date: 2015-07-10

Lead Sponsor: HaEmek Medical Center, Israel

Target Recruit Count: 60

Registration Number: NCT02077400

Locations: 🇮🇱
HaEmek medical center, Afula, Israel

Increased Cefazolin During Cesarean Delivery in Obese Population

Phase 4

Completed

Conditions: Obesity
Obesity, Morbid
Infection; Cesarean Section
Pregnancy

Interventions: Drug: Cefazolin

First Posted Date: 2014-01-30

Last Posted Date: 2021-02-02

Lead Sponsor: MemorialCare Health System

Target Recruit Count: 30

Registration Number: NCT02049944

Locations: 🇺🇸
University of California, Irvine, Orange, California, United States
🇺🇸
MemorialCare Center for Women at Miller Children's Hospital Long Beach and Long Beach Memorial Medical Center, Long Beach, California, United States

Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin

Not Applicable

Terminated

Conditions: Infection
Closed Fractures

Interventions: Drug: Vancomycin
Drug: Cefazolin

First Posted Date: 2014-01-06

Last Posted Date: 2018-07-11

Lead Sponsor: University of Tennessee

Target Recruit Count: 430

Registration Number: NCT02027532

Locations: 🇺🇸
Erlanger Health System, Chattanooga, Tennessee, United States

Antibiotic Prophylaxis in Gynecologic Laparoscopy

Not Applicable

Completed

Conditions: Infection Secondary to Surgical Procedure

Interventions: Procedure: gynecologic laparoscopy
Drug: Placebo
Drug: Cefazolin

First Posted Date: 2013-11-25

Last Posted Date: 2015-04-27

Lead Sponsor: Universidade do Vale do Sapucai

Target Recruit Count: 114

Registration Number: NCT01991834

Locations: 🇧🇷
Hospital das Clinicas Samuel Libanio, Pouso Alegre, Minas Gerais, Brazil
🇧🇷
Hospital e Maternidade Santa Paula, Pouso Alegre, Minas Gerais, Brazil