Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
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Microdose Study of Melphalan, Bortezomib and Dexamethasone
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2014-04-10
- Last Posted Date
- 2015-12-08
- Lead Sponsor
- Henrik Gregersen
- Target Recruit Count
- 6
- Registration Number
- NCT02109861
- Locations
- 🇩🇰
Department of Haematology, Aalborg University Hospital, Aalborg, Denmark
Dexamethasone and Postoperative Delirium
- Conditions
- DeliriumPostoperative Cognitive Dysfunction
- Interventions
- Drug: DexamethasoneDrug: Placebo
- First Posted Date
- 2014-04-09
- Last Posted Date
- 2021-12-21
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 200
- Registration Number
- NCT02109081
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC
- Conditions
- Chemotherapy-induced Nausea and Vomiting
- Interventions
- Drug: APF530Drug: OndansetronDrug: Ondansetron placeboDrug: APF530 placeboDrug: FosaprepitantDrug: Dexamethasone
- First Posted Date
- 2014-04-08
- Last Posted Date
- 2016-12-28
- Lead Sponsor
- Heron Therapeutics
- Target Recruit Count
- 942
- Registration Number
- NCT02106494
- Locations
- 🇺🇸
Arizona Oncology Associates, PC-HAL, Pheonix, Arizona, United States
🇺🇸Northern Indiana Research, South Bend, Indiana, United States
🇺🇸Gabrail Cancer Center Research, Canton, Ohio, United States
Concurrent Chemotherapy and Radiation Therapy for Newly Diagnosed Nasal NK Cell Lymphoma
- Conditions
- Lymphoma
- Interventions
- Radiation: Radiation TherapyDrug: DexamethasoneDrug: Etoposide phosphateDrug: IfosfamideDrug: MesnaDrug: Carboplatin
- First Posted Date
- 2014-04-08
- Last Posted Date
- 2025-01-10
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 40
- Registration Number
- NCT02106988
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine
- First Posted Date
- 2014-04-04
- Last Posted Date
- 2015-07-16
- Lead Sponsor
- Yeungnam University College of Medicine
- Target Recruit Count
- 90
- Registration Number
- NCT02104778
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Yeungnam University hospital, Daegu, Korea, Republic of
Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
- First Posted Date
- 2014-04-03
- Last Posted Date
- 2019-01-15
- Lead Sponsor
- Thammasat University
- Target Recruit Count
- 100
- Registration Number
- NCT02102815
- Locations
- 🇹🇭
Orthopaedic department, Faculty of medicine, Thammasat university, Klongluang, Pathumthani, Thailand
Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia
- Conditions
- Recurrent B Acute Lymphoblastic Leukemia
- Interventions
- Biological: BlinatumomabProcedure: Allogeneic Hematopoietic Stem Cell TransplantationDrug: CyclophosphamideDrug: AsparaginaseDrug: CytarabineDrug: DexamethasoneDrug: EtoposideDrug: Leucovorin CalciumDrug: MercaptopurineDrug: MethotrexateDrug: PegaspargaseDrug: MitoxantroneDrug: Mitoxantrone HydrochlorideOther: Pharmacological StudyRadiation: Radiation TherapyDrug: Therapeutic HydrocortisoneDrug: ThioguanineDrug: VincristineDrug: Vincristine Sulfate
- First Posted Date
- 2014-04-02
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 669
- Registration Number
- NCT02101853
- Locations
- 🇺🇸
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
🇺🇸NYP/Weill Cornell Medical Center, New York, New York, United States
🇺🇸State University of New York Upstate Medical University, Syracuse, New York, United States
Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
- Conditions
- AnemiaRefractory Multiple MyelomaRecurrent Multiple Myeloma
- Interventions
- First Posted Date
- 2014-04-02
- Last Posted Date
- 2024-05-17
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 12
- Registration Number
- NCT02101944
- Locations
- 🇺🇸
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
🇺🇸Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
🇺🇸Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States
Study of Plitidepsin (Aplidin®) in Combination With Bortezomib and Dexamethasone in Patients With Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2014-04-01
- Last Posted Date
- 2020-10-12
- Lead Sponsor
- PharmaMar
- Target Recruit Count
- 39
- Registration Number
- NCT02100657
- Locations
- 🇫🇷
Institut Gustave Roussy, Villejuif, France
🇪🇸Hospital Universitario Germans Trias I Pujol, Badalona, Barcelona, Spain
🇪🇸Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting
- Conditions
- Postoperative Nausea and Vomiting
- Interventions
- Device: Transcutaneous electrical acupoint stimulationDevice: Sham transcutaneous electrical acupoint stimulationDrug: DexamethasoneDrug: Tropisetron
- First Posted Date
- 2014-03-26
- Last Posted Date
- 2015-10-12
- Lead Sponsor
- Huashan Hospital
- Target Recruit Count
- 157
- Registration Number
- NCT02096835
- Locations
- 🇨🇳
Department of Anesthesiology, North Institute of Huashan Hospital,Fudan University, Shanghai, Shanghai, China
Drug Development Updates
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