Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

Phase 3

Recruiting

Conditions: AL Amyloidosis

Interventions: Procedure: Biospecimen Collection
Procedure: Autologous Hematopoietic Stem Cell Transplantation
Procedure: Biopsy
Procedure: Bone Marrow Aspiration
Procedure: Bone Marrow Biopsy
Drug: Bortezomib
Drug: Daratumumab and Hyaluronidase-fihj
Procedure: Computed Tomography
Drug: Melphalan
Procedure: Stem Cell Isolation
Drug: Cyclophosphamide
Drug: Dexamethasone
Procedure: Echocardiography
Other: Survey Administration
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography

First Posted Date: 2023-09-05

Last Posted Date: 2024-07-08

Lead Sponsor: SWOG Cancer Research Network

Target Recruit Count: 338

Registration Number: NCT06022939

Locations: 🇺🇸
Boston Medical Center, Boston, Massachusetts, United States
🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
🇺🇸
Siteman Cancer Center-South County, Saint Louis, Missouri, United States

and more 32 locations

Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients

Phase 4

Not yet recruiting

Conditions: Neuromuscular Scoliosis
Adolescent Idiopathic Scoliosis

Interventions: Drug: Dexamethasone

First Posted Date: 2023-09-05

Last Posted Date: 2024-06-24

Lead Sponsor: Children's Hospital Los Angeles

Target Recruit Count: 100

Registration Number: NCT06023043

Locations: 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States

A Prospective Study to Investigate Safety and Tolerability of Shorter Infusion of Fabrazyme

Phase 4

Recruiting

Conditions: Fabry's Disease

Interventions: Drug: AGALSIDASE BETA (GZ419828)
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Dexamethasone
Drug: Montelukast

First Posted Date: 2023-08-31

Last Posted Date: 2024-08-09

Lead Sponsor: Sanofi

Target Recruit Count: 18

Registration Number: NCT06019728

Locations: 🇺🇸
Emory University School of Medicine Site Number : 1005, Atlanta, Georgia, United States
🇺🇸
Lysosomal and Rare Disorders Research and Treatment Center, Inc Site Number : 1002, Fairfax, Virginia, United States
🇺🇸
Infusion Associates Site Number : 1001, Grand Rapids, Michigan, United States

and more 2 locations

Exparel vs Block for ACL Reconstruction

Phase 4

Conditions: Postoperative Pain
ACL

Interventions: Drug: Exparel 30 mL
Drug: 0.5% bupivacaine
Drug: Dexamethasone
Drug: iPACK block

First Posted Date: 2023-08-23

Last Posted Date: 2024-06-21

Lead Sponsor: Rothman Institute Orthopaedics

Target Recruit Count: 154

Registration Number: NCT06006624

Locations: 🇺🇸
Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States

Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery

Phase 4

Recruiting

Conditions: Cervical Spine Fusion

Interventions: Drug: Normal saline
Drug: Bupivacain
Drug: Dexamethasone
Drug: Epinephrine

First Posted Date: 2023-08-16

Last Posted Date: 2023-12-19

Lead Sponsor: Hartford Hospital

Target Recruit Count: 38

Registration Number: NCT05996133

Locations: 🇺🇸
Hartford Hospital, Hartford, Connecticut, United States

A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma

Phase 2

Recruiting

Conditions: B-cell Non Hodgkin Lymphoma

Interventions: Drug: Odronextamab
Biological: CAR T-cells (TBC)
Drug: Loncastuximab tesirine
Drug: Rituximab
Drug: Ifosfamide
Drug: Carboplatin
Drug: Etoposide
Drug: Etoposide Phosphate
Drug: Dexamethasone

First Posted Date: 2023-08-14

Last Posted Date: 2024-11-08

Lead Sponsor: University of Birmingham

Target Recruit Count: 210

Registration Number: NCT05991388

Locations: 🇬🇧
Bristol Royal Hospital for Children, Bristol, United Kingdom
🇬🇧
Royal Manchester Children's Hospital, Manchester, United Kingdom
🇬🇧
Birmingham Children's Hospital, Birmingham, United Kingdom