Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
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A Pharmacokinetic Study of Trabectedin in Patients With Advanced Malignancies and Hepatic Dysfunction
- Conditions
- Neoplasm MetastasesHepatic Insufficiency
- Interventions
- First Posted Date
- 2011-01-10
- Last Posted Date
- 2016-02-15
- Lead Sponsor
- Janssen Research & Development, LLC
- Target Recruit Count
- 15
- Registration Number
- NCT01273493
Ozurdex for Macular Edema Post Membrane Peeling
- Conditions
- Cellophane MaculopathyMacular EdemaRetinal EdemaEpiretinal Membrane
- Interventions
- First Posted Date
- 2011-01-10
- Last Posted Date
- 2015-05-13
- Lead Sponsor
- Retina Specialists, PC
- Target Recruit Count
- 35
- Registration Number
- NCT01273727
- Locations
- 🇺🇸
Retina Specialists PC, New York, New York, United States
Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
- Conditions
- Parapneumonic Pleural EffusionEmpyema
- Interventions
- Drug: PlaceboDrug: Dexamethasone
- First Posted Date
- 2010-12-16
- Last Posted Date
- 2015-06-01
- Lead Sponsor
- Hospital Infanta Sofia
- Target Recruit Count
- 60
- Registration Number
- NCT01261546
- Locations
- 🇪🇸
Hospital Infanta Sofia, San Sebastián de los Reyes, Madrid, Spain
🇪🇸Hospital Universitario de Getafe, Getafe, Madrid, Spain
🇪🇸Hospital Universitario Gregorio Marañón, Madrid, Spain
Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
- Conditions
- Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
- Interventions
- Biological: AlemtuzumabProcedure: Allogeneic Hematopoietic Stem Cell TransplantationProcedure: Autologous Hematopoietic Stem Cell TransplantationDrug: CyclophosphamideDrug: CytarabineDrug: DasatinibDrug: Daunorubicin HydrochlorideDrug: DexamethasoneDrug: Etoposide PhosphateBiological: FilgrastimDrug: Fludarabine PhosphateProcedure: In Vitro-Treated Peripheral Blood Stem Cell TransplantationOther: Laboratory Biomarker AnalysisDrug: Leucovorin CalciumDrug: MelphalanDrug: MercaptopurineDrug: MethotrexateBiological: PegfilgrastimOther: Pharmacological StudyDrug: TacrolimusDrug: Vincristine Sulfate
- First Posted Date
- 2010-12-08
- Last Posted Date
- 2023-04-04
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 66
- Registration Number
- NCT01256398
- Locations
- 🇺🇸
Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado, United States
🇺🇸Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana, United States
🇺🇸Longmont United Hospital, Longmont, Colorado, United States
Intra-Erythrocyte Dexamethasone Sodium Phosphate in Ataxia Teleangiectasia Patients
- First Posted Date
- 2010-12-07
- Last Posted Date
- 2024-10-10
- Lead Sponsor
- Quince Therapeutics S.p.A.
- Target Recruit Count
- 22
- Registration Number
- NCT01255358
- Locations
- 🇮🇹
University La Sapienza, Rome, Italy
🇮🇹Spedali Civili, Brescia, Italy
Docetaxel Followed by Radical Prostatectomy in Patients With High Risk Localized Prostate Cancer
- Conditions
- Prostate Cancer
- Interventions
- Drug: DocetaxelDrug: DexamethasoneDrug: EstramustineDrug: ZoladexDrug: CasodexProcedure: Radical Prostatectomy
- First Posted Date
- 2010-12-01
- Last Posted Date
- 2014-02-04
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 28
- Registration Number
- NCT01250717
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases
- First Posted Date
- 2010-11-25
- Last Posted Date
- 2023-08-28
- Lead Sponsor
- NCIC Clinical Trials Group
- Target Recruit Count
- 298
- Registration Number
- NCT01248585
- Locations
- 🇨🇦
CancerCare Manitoba, Winnipeg, Manitoba, Canada
🇨🇦Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario, Canada
🇨🇦Cancer Centre of Southeastern Ontario at Kingston, Kingston, Ontario, Canada
Carfilzomib, Pegylated Liposomal Doxorubicin Hydrochloride, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2010-11-23
- Last Posted Date
- 2019-04-08
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 40
- Registration Number
- NCT01246063
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Study Assessing Safety and Efficiency of the Lenalidomide and Dexamethasone Combination in Patients With Chronic Lymphatic Leukemia (CLL) Relapsing or Resistant to Treatment
- Conditions
- Chronic Lymphatic Leukemia
- First Posted Date
- 2010-11-23
- Last Posted Date
- 2014-04-04
- Lead Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
- Target Recruit Count
- 20
- Registration Number
- NCT01246557
- Locations
- 🇪🇸
Centro Médico Teknon, Barcelona, Spain
🇪🇸Hospital Universitari Valle Hebron, Barcelona, Spain
🇪🇸Hospital Clínico Universitario de Valencia, Valencia, Spain
Single Oral Dose of Dexamethasone Versus Five Days of Prednisone in Adult Asthma
- Conditions
- AsthmaReactive Airway Disease
- Interventions
- First Posted Date
- 2010-11-16
- Last Posted Date
- 2016-01-07
- Lead Sponsor
- Alameda County Medical Center
- Target Recruit Count
- 376
- Registration Number
- NCT01241006
- Locations
- 🇺🇸
Alameda County Medical Center, Oakland, California, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.