Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Pomalidomide in Combination With Low-Dose Dexamethasone Versus High-Dose Dexamethasone in Subjects With Refractory Multiple Myeloma or Relapsed and Refractory Multiple Myeloma and Companion Study
- First Posted Date
- 2011-03-09
- Last Posted Date
- 2018-10-24
- Lead Sponsor
- Celgene
- Target Recruit Count
- 455
- Registration Number
- NCT01311687
- Locations
- 🇧🇪
CHU UCL Mont-Godinne-Dinant asbl, Yvoir, Belgium
🇷🇺St. Petersburg Research Institute of Hematology and Blood Transfusion, St. Petersburg, Russian Federation
🇷🇺State Institution Moscow Regional Research Clinical Institute, Moscow, Russian Federation
Evaluation of Addition of Dexamethasone to Transversus Abdominis Plane (TAP) Peripheral Nerve Block
- First Posted Date
- 2011-02-24
- Last Posted Date
- 2018-09-21
- Target Recruit Count
- 24
- Registration Number
- NCT01303003
- Locations
- 🇺🇸
St. Elizabeth's Medical Center of Boston, Boston, Massachusetts, United States
Exercise Versus Corticosteroid Randomized Clinical Trial for Plantar Fasciitis
- Conditions
- Fasciitis, Plantar
- Interventions
- Other: Karaoke ExerciseOther: Balance walking exerciseDrug: DexamethasoneOther: Forefoot extension exerciseOther: Ankle inversion/eversion exerciseOther: Gastrocnemius and soleus stretchingOther: Tissue-specific plantar fascia self massage
- First Posted Date
- 2011-02-17
- Last Posted Date
- 2013-03-22
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 56
- Registration Number
- NCT01297686
- Locations
- 🇨🇦
University of British Columbia, Vancouver, British Columbia, Canada
Intravitreal Bevacizumab (Avastin®) Versus Intravitreal Dexamethasone (Ozurdex™) for Persistent Diabetic Macular Oedema
- Conditions
- Macular EdemaDiabetic Retinopathy
- Interventions
- First Posted Date
- 2011-02-17
- Last Posted Date
- 2015-06-03
- Lead Sponsor
- University of Sydney
- Target Recruit Count
- 61
- Registration Number
- NCT01298076
- Locations
- 🇦🇺
Save Sight Institute, Sydney, New South Wales, Australia
🇦🇺South West Retina, Sydney, New South Wales, Australia
🇦🇺Lions Eye Institute, Perth, Western Australia, Australia
Dexamethasone Compared to Ondansetron and Dexamethasone for Prophylaxis of Postoperative Vomiting in Children
- Conditions
- Vomiting Postoperative
- Interventions
- First Posted Date
- 2011-02-16
- Last Posted Date
- 2011-08-03
- Lead Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
- Target Recruit Count
- 134
- Registration Number
- NCT01297010
Thalidomide Plus Dexamethasone as Maintenance Therapy for Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2011-02-15
- Last Posted Date
- 2011-02-15
- Target Recruit Count
- 213
- Registration Number
- NCT01296503
- Locations
- 🇧🇷
Universidade Estadual de Campinas, Campinas, São Paulo, Brazil
🇧🇷Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil
🇧🇷Universidade de São Paulo- Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
- Conditions
- Negative FeedbackACTHCortisol ResistanceMineralcorticoidGlucocorticoid
- Interventions
- First Posted Date
- 2011-02-11
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Target Recruit Count
- 51
- Registration Number
- NCT01294319
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Intra-erythrocyte Dexamethasone Versus Placebo in Patients With Steroid-dependent Crohn's Disease
- First Posted Date
- 2011-01-14
- Last Posted Date
- 2024-06-03
- Lead Sponsor
- Quince Therapeutics S.p.A.
- Target Recruit Count
- 51
- Registration Number
- NCT01277289
- Locations
- 🇷🇴
Spitalul Clinic Judetean De Urgenta, Cluj-Napoca, Romania
🇮🇹Ospedale Careggi, Firenze, Italy
🇮🇹Policlinico Sant'Orsola, Bologna, Italy
Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Stage II, III, or IV Ovarian Cancer
- Conditions
- Stage IIC Ovarian CancerStage IIIC Fallopian Tube CancerStage IV Ovarian CancerNausea and VomitingOvarian Endometrioid AdenocarcinomaOvarian Mucinous CystadenocarcinomaStage IIB Fallopian Tube CancerStage IIIA Fallopian Tube CancerStage IIA Ovarian CancerStage IIIB Ovarian Cancer
- Interventions
- Procedure: Adjuvant TherapyDrug: AprepitantDrug: CarboplatinDrug: CisplatinDrug: DexamethasoneDrug: Granisetron Transdermal PatchProcedure: Management of Therapy ComplicationsOther: Questionnaire Administration
- First Posted Date
- 2011-01-12
- Last Posted Date
- 2018-05-22
- Lead Sponsor
- Gynecologic Oncology Group
- Target Recruit Count
- 4
- Registration Number
- NCT01275664
- Locations
- 🇺🇸
Women and Infants Hospital, Providence, Rhode Island, United States
🇺🇸Sudarshan K Sharma MD Limted-Gynecologic Oncology, Hinsdale, Illinois, United States
Corticosteroids as Additive in Temporomandibular Joint (TMJ) Arthrocentesis
- First Posted Date
- 2011-01-12
- Last Posted Date
- 2011-01-12
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 28
- Registration Number
- NCT01275014
- Locations
- 🇳🇱
University Medical Centre Groningen, Groningen, Netherlands
Drug Development Updates
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