Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Venetoclax Combined With Dexamethasone and Etoposide in HLH

Phase 1

Recruiting

Conditions: Hemophagocytic Lymphohistiocytosis

Interventions: Drug: Venetoclax
Drug: Dexamethasone
Drug: Etoposide

First Posted Date: 2022-09-19

Last Posted Date: 2022-09-19

Lead Sponsor: Beijing Friendship Hospital

Target Recruit Count: 20

Registration Number: NCT05546060

Locations: 🇨🇳
Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing, China

Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

Phase 4

Completed

Conditions: Nausea and Vomiting

Interventions: Other: normal saline
Drug: metoclopramide
Drug: tropisetron
Drug: dexamethasone

First Posted Date: 2022-09-09

Last Posted Date: 2024-04-02

Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Target Recruit Count: 200

Registration Number: NCT05533281

Locations: 🇨🇳
The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China

Dexamethasone as Adjuvant to Bupivacaine in Suprazygomatic Maxillary Nerve Block

Not Applicable

Not yet recruiting

Conditions: Nerve Block

Interventions: Drug: Bupivacaine
Drug: Dexamethasone

First Posted Date: 2022-09-07

Last Posted Date: 2023-02-22

Lead Sponsor: Assiut University

Target Recruit Count: 34

Registration Number: NCT05530811

Selinexor, Venetoclax, and Dexamethasone (XVenD) in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma

Phase 2

Recruiting

Conditions: Relapsed and Refractory Multiple Myeloma

Interventions: Drug: Selinexor
Drug: Venetoclax
Drug: Dexamethasone

First Posted Date: 2022-09-07

Last Posted Date: 2024-03-13

Lead Sponsor: University of Miami

Target Recruit Count: 33

Registration Number: NCT05530421

Locations: 🇺🇸
University of Miami, Lennar Foundation Medical Center, Coral Gables, Florida, United States
🇺🇸
University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida, United States
🇺🇸
University of Miami, Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

Iberdomide-dexamethasone Alone or in Combination With Standard MM Treatment Regimens in Transplant Ineligible Newly Diagnosed Patients.

Phase 2

Not yet recruiting

Conditions: Multiple Myeloma

Interventions: Drug: Iberdomide
Drug: Dexamethasone
Drug: Daratumumab

First Posted Date: 2022-09-02

Last Posted Date: 2022-09-02

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 140

Registration Number: NCT05527340

Locations: 🇪🇸
Hospital Universitario de Canarias, La Laguna, Spain
🇪🇸
Hospital Universitario 12 de Octubre, Madrid, Spain
🇪🇸
Clínica Universidad de Navarra, Pamplona, Spain

and more 6 locations

Comparison Between the Quadratus Lumborum Block ,Erector Spinae Plane Block in Lower Abdominal Surgery

Not Applicable

Recruiting

Conditions: Lower Abdominal Surgery

Interventions: Drug: Bupivacaine Hydrochloride
Device: Ultrasound device
Drug: Dexamethasone
Device: echogenic needle

First Posted Date: 2022-09-01

Last Posted Date: 2022-10-13

Lead Sponsor: Fayoum University Hospital

Target Recruit Count: 48

Registration Number: NCT05524038

Locations: 🇪🇬
Fayoum University hospital, Al Fayyūm, Fayoum Governorate, Egypt

Short-course High-dose Prednisone and Dexamethasone in Children With ITP

Phase 4

Recruiting

Conditions: Child, Only
Immune Thrombocytopenia
Glucocorticoids

Interventions: Drug: Prednisone
Drug: Dexamethasone

First Posted Date: 2022-08-31

Last Posted Date: 2024-05-16

Lead Sponsor: Fujian Medical University Union Hospital

Target Recruit Count: 608

Registration Number: NCT05522465

Locations: 🇨🇳
Children with newly dignosed ITP, Fujian, Fujian, China

A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias

Phase 1

Withdrawn

Conditions: Acute Leukemias
Acute Leukemia of Ambiguous Lineage
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia

Interventions: Drug: JNJ-75276617
Drug: Fludarabine
Drug: Cytarabine
Drug: Intrathecal Chemotherapy
Drug: Dexamethasone
Drug: Vincristine
Drug: Pegaspargase

First Posted Date: 2022-08-30

Last Posted Date: 2024-08-22

Lead Sponsor: Janssen Research & Development, LLC

Registration Number: NCT05521087

Locations: 🇺🇸
Memorial Sloan Kettering, New York, New York, United States
🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

and more 8 locations

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Phase 3

Recruiting

Conditions: Relapsed or Refractory Multiple Myeloma

Interventions: Drug: mezigdomide
Drug: Pomalidomide
Drug: Bortezomib
Drug: Dexamethasone

First Posted Date: 2022-08-29

Last Posted Date: 2024-12-18

Lead Sponsor: Celgene

Target Recruit Count: 810

Registration Number: NCT05519085

Locations: 🇺🇸
Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi, United States
🇺🇸
Astera Cancer Care, East Brunswick, New Jersey, United States
🇺🇸
Dana-Farber Cancer Institute, Boston, Massachusetts, United States

and more 247 locations

Efficacy of Dexamethasone in Treatment of Meconium Aspiration Syndrome

Not Applicable

Completed

Conditions: Efficacy, Self

Interventions: Drug: Dexamethasone

First Posted Date: 2022-08-26

Last Posted Date: 2022-08-26

Lead Sponsor: Services Institute of Medical Sciences, Pakistan

Target Recruit Count: 120

Registration Number: NCT05517499

Locations: 🇵🇰
Services Hospital Lahore, Lahore, Punjab, Pakistan

Drug Development Updates

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