Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial

Phase 1

Recruiting

Conditions: Recurrent Multiple Myeloma
Refractory Multiple Myeloma

Interventions: Drug: Carfilzomib
Drug: Dexamethasone
Other: Quality-of-Life Assessment
Drug: Pomalidomide
Other: Questionnaire Administration
Drug: Selinexor
Procedure: X-Ray Imaging
Procedure: Computed Tomography
Procedure: Positron Emission Tomography
Procedure: Bone Marrow Biopsy
Procedure: Bone Marrow Aspiration
Procedure: Biospecimen Collection

First Posted Date: 2021-02-21

Last Posted Date: 2024-01-17

Lead Sponsor: Mayo Clinic

Target Recruit Count: 81

Registration Number: NCT04764942

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Dexamethasone and Robotic-assisted Hysterectomy

Not Applicable

Completed

Conditions: Inflammatory Response
Pain, Postoperative
Nausea, Postoperative
Incontinence
Sexual Behavior

Interventions: Other: Placebo
Drug: Dexamethasone phosphate

First Posted Date: 2021-02-21

Last Posted Date: 2024-06-04

Lead Sponsor: Herning Hospital

Target Recruit Count: 109

Registration Number: NCT04762381

Locations: 🇩🇰
Gyn. Dept.;Aabenraa Hospital, Sygehus Sønderjylland, Aabenraa, Denmark

Comparison Between Prednisolone and Dexamethasone on Mortality in Patients on Oxygen Therapy, With CoViD-19

Phase 3

Completed

Conditions: Coronavirus Infection

Interventions: Drug: DEXAMETHASONE
Drug: PREDNISOLONE

First Posted Date: 2021-02-21

Last Posted Date: 2024-05-06

Lead Sponsor: Hôpital NOVO

Target Recruit Count: 89

Registration Number: NCT04765371

Locations: 🇫🇷
Department of Infectious Medicine, Hospital of Gonesse, Gonesse, France
🇫🇷
Department of Pneumology and Infectious Diseases, Hospital of Saint-Quentin, Saint-Quentin, France
🇫🇷
Department of Emergency, Hospital Victor Dupouy, Argenteuil, France

and more 5 locations

The Efficacy and Safety of Pomalidomide and Bendamustine With Dexamethasone in Relapsed or Refractory Multiple Myeloma

Phase 1

Conditions: Relapsed, Refractory, Multiple Myeloma

Interventions: Drug: Pomalidomide
Drug: Bendamustine
Drug: Dexamethasone

First Posted Date: 2021-02-21

Last Posted Date: 2021-02-21

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 56

Registration Number: NCT04762745

Locations: 🇨🇳
Sun Yat-sen University Cancer Center, Guangzhou, Please Select, China

Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myeloma

Phase 2

Recruiting

Conditions: Recurrent Plasma Cell Myeloma
Refractory Plasma Cell Myeloma

Interventions: Drug: Carfilzomib
Biological: Daratumumab
Drug: Dexamethasone
Other: Quality-of-Life Assessment
Drug: Selinexor

First Posted Date: 2021-02-16

Last Posted Date: 2024-05-28

Lead Sponsor: Academic and Community Cancer Research United

Target Recruit Count: 52

Registration Number: NCT04756401

Locations: 🇺🇸
Hackensack University Medical Center, Hackensack, New Jersey, United States
🇺🇸
State University of New York Upstate Medical University, Syracuse, New York, United States
🇺🇸
UNC Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

and more 1 locations

Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis

Phase 1

Active, not recruiting

Conditions: AL Amyloidosis

Interventions: Drug: Bortezomib
Drug: Cyclophosphamide
Drug: Dexamethasone
Biological: Isatuximab

First Posted Date: 2021-02-15

Last Posted Date: 2024-06-26

Lead Sponsor: Emory University

Target Recruit Count: 11

Registration Number: NCT04754945

Locations: 🇺🇸
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
🇺🇸
Emory University Hospital Midtown, Atlanta, Georgia, United States
🇺🇸
Karmanos Cancer Institute, Detroit, Michigan, United States

and more 3 locations

Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction

Not Applicable

Completed

Conditions: Hypocalcemia
Vocal Cord Dysfunction
Thyroid Diseases

Interventions: Drug: Placebo
Drug: Dexamethasone

First Posted Date: 2021-02-12

Last Posted Date: 2021-02-12

Lead Sponsor: Holy Family Hospital, Pakistan

Target Recruit Count: 192

Registration Number: NCT04752852

Management of Pain in Lumbar Arthrodesis

Phase 4

Recruiting

Conditions: Pain, Postoperative

Interventions: Drug: Ketamine
Drug: Dexamethasone
Drug: Physiologic saline

First Posted Date: 2021-02-12

Last Posted Date: 2024-02-08

Lead Sponsor: Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta

Target Recruit Count: 128

Registration Number: NCT04751175

Locations: 🇪🇸
Hospital Dr Josep Trueta, Girona, Spain

DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia

Phase 1

Completed

Conditions: Recurrent Chronic Myelomonocytic Leukemia
Hematopoietic and Lymphoid Cell Neoplasm
Recurrent Acute Myeloid Leukemia
Recurrent Acute Lymphoblastic Leukemia
Recurrent Myelodysplastic Syndrome
Refractory Acute Lymphoblastic Leukemia
Refractory Acute Myeloid Leukemia
Refractory Chronic Myelomonocytic Leukemia
Refractory Myelodysplastic Syndrome