Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Glucocorticoid Therapy in Coronavirus Disease COVID-19 Patients
- Conditions
- Corona Virus Infection
- Interventions
- First Posted Date
- 2021-03-03
- Last Posted Date
- 2022-06-14
- Lead Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
- Target Recruit Count
- 127
- Registration Number
- NCT04780581
- Locations
- 🇪🇸
Complejo Asistencial Universitario de León, León, Spain
🇪🇸Hospital Clínico Universitario de Valladolid, Valladolid, Spain
🇪🇸Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries
- Conditions
- Intraoperativ Pain
- Interventions
- First Posted Date
- 2021-03-03
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT04779060
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Effectiveness of Combined Erector Spinae and Pecto-intercostal Fascial Plane Blocks Versus Thoracic Paravertebral Block in Perioperative Pain in Modified Radical Mastectomy
- Conditions
- Modified Radical Mastectomy
- Interventions
- First Posted Date
- 2021-03-03
- Last Posted Date
- 2023-03-13
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT04778267
- Locations
- 🇪🇬
Kase Al Aini teaching hospital, Cairo, Kasr Al Aini, Egypt
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies
- Conditions
- Sickle Beta ThalassemiaBeta Thalassemia MajorSickle Beta 0 ThalassemiaSickle Beta Plus ThalassemiaSickle Cell-SS DiseaseSickle Cell Disease
- Interventions
- Drug: BortezomibDrug: BusulfanDrug: CyclophosphamideDrug: DexamethasoneDrug: Fludarabine PhosphateProcedure: Hematopoietic Cell TransplantationBiological: Lapine T-Lymphocyte Immune GlobulinDrug: Mycophenolate MofetilProcedure: PlasmapheresisBiological: RituximabDrug: Tacrolimus
- First Posted Date
- 2021-03-02
- Last Posted Date
- 2024-10-24
- Lead Sponsor
- M.D. Anderson Cancer Center
- Registration Number
- NCT04776850
DARA RVD For High Risk SMM
- Conditions
- Multiple MyelomaHigh-risk Smoldering Multiple Myeloma
- Interventions
- First Posted Date
- 2021-03-01
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- Omar Nadeem, MD
- Target Recruit Count
- 61
- Registration Number
- NCT04775550
- Locations
- 🇺🇸
Stamford Hospital, Stamford, Connecticut, United States
🇺🇸Brigham and Women's Hospital, Boston, Massachusetts, United States
🇺🇸Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Iberdomide Alone or in Combination With Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma
- Conditions
- Smoldering Plasma Cell Myeloma
- Interventions
- First Posted Date
- 2021-03-01
- Last Posted Date
- 2024-07-15
- Lead Sponsor
- Emory University
- Target Recruit Count
- 68
- Registration Number
- NCT04776395
- Locations
- 🇺🇸
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
The Effectiveness of Preemptive Nebulized Dexamethasone in Reducing Post-Operative Sore Throat in Supraglottic Airway
- Conditions
- HoarsenessSupraglottic Airway DevicesSore ThroatDexamethasone
- Interventions
- First Posted Date
- 2021-02-25
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- Universiti Sains Malaysia
- Target Recruit Count
- 140
- Registration Number
- NCT04771026
- Locations
- 🇲🇾
University of Science Malaysia Hospital, Kubang Kerian, Kelantan, Malaysia
PROUD Study - Preventing Opioid Use Disorders
- Conditions
- Opioid UseAnesthesia
- Interventions
- Behavioral: Guided mindfulness exercisesOther: Self-administered aromatherapyDrug: Baby aspirinDrug: Tylenol/AcetaminophenDrug: PregabalinDrug: PrednisoneDrug: MeloxicamDrug: PrilosecDrug: TramadolDrug: VoltarenDrug: ZofranDrug: PepcidDrug: ReglanDrug: VersedDrug: LidocaineDrug: PropofolDrug: AncefDrug: Tranexamic Acid (TXA)Drug: DecadronDrug: Bupivacaine hydrochlorideDrug: Toradol
- First Posted Date
- 2021-02-23
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- Emory University
- Target Recruit Count
- 57
- Registration Number
- NCT04766996
- Locations
- 🇺🇸
Emory University Orthopaedic and Spine Hospital, Atlanta, Georgia, United States
Verification of the Efficacy/safety of the Intratympanic Drug Delivery for Hearing Loss
- Conditions
- Hearing Loss, Noise-InducedHearing Loss, OtotoxicMeniere DiseaseHearing Loss, Sudden
- Interventions
- First Posted Date
- 2021-02-23
- Last Posted Date
- 2024-10-24
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 15
- Registration Number
- NCT04766853
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Selinexor, Pomalidomide, and Dexamethasone With or Without Carfilzomib for the Treatment of Patients With Relapsed Refractory Multiple Myeloma, The SCOPE Trial
- Conditions
- Recurrent Multiple MyelomaRefractory Multiple Myeloma
- Interventions
- Drug: CarfilzomibDrug: DexamethasoneOther: Quality-of-Life AssessmentDrug: PomalidomideOther: Questionnaire AdministrationDrug: SelinexorProcedure: X-Ray ImagingProcedure: Computed TomographyProcedure: Positron Emission TomographyProcedure: Bone Marrow BiopsyProcedure: Bone Marrow AspirationProcedure: Biospecimen Collection
- First Posted Date
- 2021-02-21
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 81
- Registration Number
- NCT04764942
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.