Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Dexametasone Versus Dexametasone Plus Dexmedetomidine in Nerve Blocks
- Conditions
- AnalgesiaPain, AcuteUpper Extremity Injury
- Interventions
- Drug: Dexmedetomidine-DexamethasoneDrug: Dexamethasone
- First Posted Date
- 2021-05-06
- Last Posted Date
- 2022-03-04
- Lead Sponsor
- University of Chile
- Target Recruit Count
- 50
- Registration Number
- NCT04875039
- Locations
- 🇨🇱
Hospital Clínico Universidad de Chile, Santiago, Metropolitan, Chile
Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving Paclitaxel
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8Prognostic Stage IIIA Breast Cancer AJCC v8Prognostic Stage IV Breast Cancer AJCC v8Anatomic Stage 0 Breast Cancer AJCC v8Anatomic Stage IA Breast Cancer AJCC v8Anatomic Stage IB Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIA Breast Cancer AJCC v8Anatomic Stage IIB Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8
- Interventions
- Drug: CimetidineDrug: DexamethasoneDrug: DiphenhydramineDrug: FamotidineDrug: PaclitaxelOther: Quality-of-Life AssessmentDrug: Ranitidine
- First Posted Date
- 2021-04-28
- Last Posted Date
- 2024-08-09
- Target Recruit Count
- 129
- Registration Number
- NCT04862585
- Locations
- 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Human Intravenous Interferon Beta-Ia Safety and Preliminary Efficacy in Hospitalized Subjects With COVID-19
- First Posted Date
- 2021-04-27
- Last Posted Date
- 2023-07-21
- Lead Sponsor
- Faron Pharmaceuticals Ltd
- Target Recruit Count
- 7
- Registration Number
- NCT04860518
- Locations
- 🇺🇸
Newton-Wellesley Hospital, Newton, Massachusetts, United States
🇺🇸Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States
Effect of Honey and Dexamethason on Extraction Healing
- Conditions
- Impacted Third Molar Tooth
- Interventions
- First Posted Date
- 2021-04-19
- Last Posted Date
- 2021-07-22
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 80
- Registration Number
- NCT04848259
- Locations
- 🇸🇦
Vision colleges, Jeddah, Saudi Arabia
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis
- Conditions
- AL Amyloidosis
- Interventions
- Procedure: Biospecimen CollectionProcedure: Bone Marrow Aspiration and BiopsyProcedure: Computed TomographyDrug: DexamethasoneDrug: Ixazomib CitrateProcedure: Magnetic Resonance ImagingProcedure: Positron Emission TomographyProcedure: Transabdominal UltrasoundDrug: VenetoclaxProcedure: X-Ray Imaging
- First Posted Date
- 2021-04-19
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 24
- Registration Number
- NCT04847453
- Locations
- 🇺🇸
City of Hope Comprehensive Cancer Center LAO, Duarte, California, United States
🇺🇸City of Hope Comprehensive Cancer Center, Duarte, California, United States
🇺🇸University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients
- Conditions
- MyelomaMyeloma MultipleRefractory Multiple Myeloma
- Interventions
- First Posted Date
- 2021-04-13
- Last Posted Date
- 2023-10-25
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 4
- Registration Number
- NCT04843579
- Locations
- 🇺🇸
Weill Cornell Medicine - Multiple Myeloma Center, New York, New York, United States
🇺🇸NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States
Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
- Conditions
- Mesothelioma
- Interventions
- Biological: LMB-100Drug: ipilimumabDrug: DiphenhydramineDrug: FamotidineDrug: AcetaminophenDrug: DexamethasoneProcedure: BiopsyDiagnostic Test: FDG-PETDiagnostic Test: CT CAPDiagnostic Test: MRIDiagnostic Test: ECGDiagnostic Test: Echocardiogram
- First Posted Date
- 2021-04-12
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 2
- Registration Number
- NCT04840615
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Does the Single Use of Intravenous Dexamethasone Enhance Analgesic Quality of Pudendal Analgesia in Children Undergoing Hypospadias Surgery?
- Conditions
- Pediatric Patients Undergoing Hypospadias Surgery
- Interventions
- Drug: normal salineDrug: dexamethasone
- First Posted Date
- 2021-04-08
- Last Posted Date
- 2022-08-23
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 46
- Registration Number
- NCT04836962
- Locations
- 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of
Isatuximab, Pomalidomide, Elotuzumab and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2021-04-08
- Last Posted Date
- 2024-02-07
- Lead Sponsor
- Medical College of Wisconsin
- Target Recruit Count
- 53
- Registration Number
- NCT04835129
- Locations
- 🇺🇸
The University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸Froedtert Hospital & the Medical College of Wisconsin, Milwaukee, Wisconsin, United States
DEXamethasone EARLY Administration in Hospitalized Patients With Covid-19 Pneumonia
- Conditions
- COVID-19Acute Respiratory Distress SyndromePneumonia, Viral
- Interventions
- First Posted Date
- 2021-04-08
- Last Posted Date
- 2023-03-01
- Lead Sponsor
- Hospital Universitario Infanta Leonor
- Target Recruit Count
- 126
- Registration Number
- NCT04836780
- Locations
- 🇪🇸
Hospital Universitario Clínico San Carlos, Madrid, Spain
🇪🇸Hospital Emergencias Enfermera Isabel Zendal, Madrid, Spain
🇪🇸Hospital Universitario Infanta Leonor, Madrid, Spain
Drug Development Updates
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