Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Comparison Between Adjuvants Added to Bupivacaine in Adductor Canal Block
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2021-05-19
- Last Posted Date
- 2022-01-25
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 120
- Registration Number
- NCT04892420
- Locations
- 🇪🇬
Ismail Mohammed Ibrahim, Cairo, Egypt
Belantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple Myeloma
- Conditions
- Plasma Cell MyelomaRecurrent Plasma Cell MyelomaRefractory Plasma Cell Myeloma
- Interventions
- Biological: Belantamab MafodotinBiological: DaratumumabDrug: LenalidomideDrug: DexamethasoneOther: Quality-of-Life AssessmentProcedure: Biospecimen CollectionProcedure: Skeletal Survey X-RayProcedure: Low Dose Computed Tomography of the Whole BodyProcedure: Bone Marrow AspirationProcedure: Bone Marrow Biopsy
- First Posted Date
- 2021-05-19
- Last Posted Date
- 2024-03-29
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 5
- Registration Number
- NCT04892264
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Selinexor in Combination With Thalidomide and Dexamethasone in RRMM
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2021-05-18
- Last Posted Date
- 2021-05-18
- Lead Sponsor
- Li Zheng
- Target Recruit Count
- 48
- Registration Number
- NCT04891744
- Locations
- 🇨🇳
West China Hospital of Sichuan University, Chengdu, Sichuan, China
Clinical Trial to Evaluate the Efficacy of Different Treatments in Patients With COVID-19
- Conditions
- SARS-CoV-2 Infection
- Interventions
- Drug: Baricitinib + dexamethasoneDrug: Emtricitabine/Tenofovir Disoproxil Fumarate 200 MG-245 MG Oral Tablet [TRUVADA]Drug: Dexamethasone
- First Posted Date
- 2021-05-18
- Last Posted Date
- 2024-03-06
- Target Recruit Count
- 356
- Registration Number
- NCT04890626
- Locations
- 🇪🇸
Hospital Universitario La Paz, Madrid, Spain
Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery
- Conditions
- Intrahepatic Cholangiocarcinoma
- Interventions
- Drug: GemcitabineDrug: OxaliplatinDrug: DexamethasoneDrug: Floxuridine (FUDR)Device: Implanted Medical Device
- First Posted Date
- 2021-05-18
- Last Posted Date
- 2024-06-07
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 164
- Registration Number
- NCT04891289
- Locations
- 🇺🇸
National Heart, Lung, and Blood Institute (NIH) (Data Collection Only), Bethesda, Maryland, United States
🇺🇸Washington University (Data Collection Only), Saint Louis, Missouri, United States
🇺🇸Memorial Sloan Kettering Monmouth - Limited Protocol Activities, Middletown, New Jersey, United States
Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation
- Conditions
- Distal Radius Fracture
- Interventions
- Other: No dexamethasoneDrug: Dexamethasone
- First Posted Date
- 2021-05-17
- Last Posted Date
- 2023-10-23
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 70
- Registration Number
- NCT04889547
- Locations
- 🇺🇸
North Shore University Hospital, Manhasset, New York, United States
Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma
- Conditions
- Recurrent Multiple MyelomaRefractory Multiple Myeloma
- Interventions
- Drug: CarfilzomibDrug: DexamethasoneBiological: IsatuximabDrug: PomalidomideProcedure: Bone Marrow BiopsyProcedure: Bone Marrow AspirationProcedure: Skeletal Survey X-RayProcedure: Computed TomographyProcedure: Positron Emission TomographyProcedure: Magnetic Resonance Imaging
- First Posted Date
- 2021-05-12
- Last Posted Date
- 2024-07-03
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 37
- Registration Number
- NCT04883242
- Locations
- 🇺🇸
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Study to Evaluate Tolerability of Iberdomide (CC-220) in Combination With Polatuzumab Vedotin Plus Rituximab or Tafasitamab or Rituximab Plus Chemotherapy in B-cell Lymphoma
- Conditions
- Lymphoma, B-Cell
- Interventions
- First Posted Date
- 2021-05-11
- Last Posted Date
- 2021-10-05
- Lead Sponsor
- Celgene
- Registration Number
- NCT04882163
- Locations
- 🇬🇧
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
🇺🇸Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸Avera Cancer Institute, Sioux Falls, South Dakota, United States
Post-operative Course of Dexamethasone to Reduce Tonsillectomy Morbidity
- Conditions
- AdenotonsillectomyAnalgesiaSurgery
- Interventions
- First Posted Date
- 2021-05-10
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- David Chi, MD
- Target Recruit Count
- 215
- Registration Number
- NCT04879823
- Locations
- 🇺🇸
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇺🇸Children's Hospital North Surgery Center, Sewickley, Pennsylvania, United States
ATG-010(Selinexor) in Combination With Chemotherapy in RRMM
- Conditions
- Multiple Myeloma
- Interventions
- Drug: Selinexor (80mg/d)Drug: Selinexor (100mg/d)Drug: Pegylated liposomal doxorubicinDrug: DexamethasoneDrug: Cyclophosphamide
- First Posted Date
- 2021-05-07
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- Chunyan Sun, MD
- Target Recruit Count
- 50
- Registration Number
- NCT04877275
- Locations
- 🇨🇳
Henan Cancer Hospital, Zhengzhou, Henan, China
🇨🇳The First Affiliated Hospital of Air Force Medical University, Xi'an, Shanxi, China
🇨🇳Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
Drug Development Updates
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