Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Factorial Randomized Trial of Rendesivir and Baricitinib Plus Dexamethasone for COVID-19 (the AMMURAVID Trial)
- Conditions
- Covid19
- Interventions
- First Posted Date
- 2021-04-06
- Last Posted Date
- 2021-04-06
- Lead Sponsor
- ASST Fatebenefratelli Sacco
- Target Recruit Count
- 4000
- Registration Number
- NCT04832880
- Locations
- 🇮🇹
Ospedale di Ferrara, Ferrara, Italy
🇮🇹ASST Santi Paolo e Carlo, Milan, Italy
🇮🇹ASST Fatebenefratelli-Sacco, Milan, Italy
Corticosteroids as an Additional Treatment for Mastoiditis In Children
- First Posted Date
- 2021-04-02
- Last Posted Date
- 2021-04-06
- Lead Sponsor
- ori snapiri
- Target Recruit Count
- 50
- Registration Number
- NCT04828525
Oral Statins and Protection From Hearing Loss
- Conditions
- Sudden Sensorineural Hearing Loss
- Interventions
- First Posted Date
- 2021-04-01
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 100
- Registration Number
- NCT04826237
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
Dose Escalation and Expansion Study of CM313 in Subjects With Relapsed or Refractory Multiple Myeloma and Lymphoma
- Conditions
- Multiple MyelomaLymphoma
- Interventions
- First Posted Date
- 2021-03-26
- Last Posted Date
- 2021-11-12
- Lead Sponsor
- Keymed Biosciences Co.Ltd
- Target Recruit Count
- 87
- Registration Number
- NCT04818372
- Locations
- 🇨🇳
Beijing Chao-Yang Hospital, Capital Medical University (West Branch), Beijing, Beijing, China
🇨🇳Beijing Chao-Yang Hospital, Beijing, Beijing, China
🇨🇳Peking University Third Hospital, Beijing, Beijing, China
Dexamethasone Before Elective Cesarean Section at Term in Reducing Neonatal Respiratory Distress Syndrome
- First Posted Date
- 2021-03-25
- Last Posted Date
- 2021-03-26
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 950
- Registration Number
- NCT04816097
Belantamab Mafodotin in Newly Diagnosed Transplant Eligible Multiple Myeloma Patients
- Conditions
- Multiple Myeloma
- Interventions
- Drug: Belantamab mafodotinDrug: BortezomibDrug: LenalidomideDrug: DexamethasoneProcedure: Autologous stem cell transplant (ASCT)
- First Posted Date
- 2021-03-17
- Last Posted Date
- 2021-12-06
- Lead Sponsor
- PETHEMA Foundation
- Target Recruit Count
- 50
- Registration Number
- NCT04802356
- Locations
- 🇪🇸
Hospital Gregorio Marañon, Madrid, Comunidad Autónoma De Madrid, Spain
🇪🇸Institut Catala d'Oncologia (ICO) Hospitalet, Hospitalet de Llobregat, Cataluña, Spain
🇪🇸Clinica Universidad Navarra (CUN), Pamplona, Navarra, Spain
Dexamethasone for Post Traumatic Headache
- Conditions
- Post-Traumatic Headache
- Interventions
- First Posted Date
- 2021-03-16
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 162
- Registration Number
- NCT04799015
- Locations
- 🇺🇸
Montefiore, Bronx, New York, United States
Effectiveness of Intratympanic Dexamethasone With Ligmocaine for Alleviation of Tinnitus
- First Posted Date
- 2021-03-15
- Last Posted Date
- 2021-03-15
- Lead Sponsor
- Combined Military Hospital, Pakistan
- Target Recruit Count
- 264
- Registration Number
- NCT04798391
- Locations
- 🇵🇰
Combined Military Hospital, Quetta, Balochistan, Pakistan
Study of the Excretion of Orally Administered Corticosteroids for the Improval of the Detection of Said Substances in Anti-doping Controls
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2021-03-10
- Last Posted Date
- 2021-04-01
- Lead Sponsor
- Parc de Salut Mar
- Target Recruit Count
- 50
- Registration Number
- NCT04791345
- Locations
- 🇪🇸
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Trial to Determine the Efficacy/Safety of Plitidepsin vs Control in Patients With Moderate COVID-19 Infection
- Conditions
- COVID-19 Infection
- Interventions
- First Posted Date
- 2021-03-05
- Last Posted Date
- 2023-03-09
- Lead Sponsor
- PharmaMar
- Target Recruit Count
- 205
- Registration Number
- NCT04784559
- Locations
- 🇧🇷
Hospital Felicio Rocho, Belo Horizonte, MG, Brazil
🇲🇽Universidad Autonoma de Nuevo Leon - Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, NL, Mexico
🇷🇴Institutul National De Boli Infectioase "Prof. Dr. Matei Bals", Bucharest, Romania
Drug Development Updates
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