Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)

Not Applicable

Conditions: Keloid
Hypertrophic Scar
Scars
Scarring

Interventions: Drug: Betamethasone acetate + Betamethasone sodium phosphate
Drug: Dexamethasone sodium phosphate
Drug: Methylprednisolone acetate
Drug: Triamcinolone acetonide

First Posted Date: 2020-10-20

Last Posted Date: 2020-10-20

Lead Sponsor: Tel-Aviv Sourasky Medical Center

Target Recruit Count: 40

Registration Number: NCT04593706

Romiplostim, Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

Phase 2

Conditions: Immune Thrombocytopenia
Thrombotic Thrombocytopenic Purpura

Interventions: Drug: Romiplostim
Drug: Rituximab
Drug: Dexamethasone

First Posted Date: 2020-10-19

Last Posted Date: 2020-10-19

Lead Sponsor: David Gomez Almaguer

Target Recruit Count: 12

Registration Number: NCT04588194

Locations: 🇲🇽
Servicio de Hematología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico

Efficacy of a Single Dose Dexamethasone in Reducing the Postembolization Syndrome in Men Undergoing Prostatic Artery Embolization for Benign Prostatic Hyperplasia

Phase 4

Conditions: Prostatic Hyperplasia

Interventions: Drug: Saline
Drug: Dexamethasone

First Posted Date: 2020-10-19

Last Posted Date: 2022-03-22

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 60

Registration Number: NCT04588857

Locations: 🇩🇰
Rigshospitalet, Copenhagen, Denmark

A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.

Phase 1

Completed

Conditions: Acute Myeloid Leukemia

Interventions: Drug: RO7283420
Drug: Tocilizumab
Drug: Dasatinib
Drug: Dexamethasone
Drug: Paracetamol/acetaminophen
Drug: Diphenhydramine

First Posted Date: 2020-10-08

Last Posted Date: 2024-06-03

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 59

Registration Number: NCT04580121

Locations: 🇮🇹
Ospedale Santa Chiara; Unita Operativa Di Ematologia, Pisa, Toscana, Italy
🇺🇸
UC Davis Comprehensive Cancer Center, Sacramento, California, United States
🇩🇰
Rigshospitalet; Hæmatologisk Klinik, Klinisk Afprøvnings Team KAT, København Ø, Denmark

and more 20 locations

Study to Determine Recommended Phase 2 Dose of Intravenous (IV) Eftozanermin Alfa in Combination With IV or Subcutaneous (SC) Bortezomib and Oral Dexamethasone Tablet and to Assess Change in Disease Symptoms in Adult Participants With Relapsed or Refractory Multiple Myeloma

Phase 1

Active, not recruiting

Conditions: Multiple Myeloma

Interventions: Drug: Eftozanermin alfa
Drug: Bortezomib
Drug: Dexamethasone

First Posted Date: 2020-09-30

Last Posted Date: 2024-08-14

Lead Sponsor: AbbVie

Target Recruit Count: 40

Registration Number: NCT04570631

Locations: 🇫🇷
CHRU Lille - Hopital Claude Huriez /ID# 222302, Lille, Nord, France
🇫🇷
Institut Gustave Roussy /ID# 223951, Villejuif Cedex, Val-de-Marne, France
🇺🇸
Norton Healthcare Pavilion /ID# 222918, Louisville, Kentucky, United States

and more 16 locations

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Phase 3

Recruiting

Conditions: RISS Stage I Plasma Cell Myeloma
RISS Stage II Plasma Cell Myeloma
Plasma Cell Myeloma

Interventions: Drug: Bortezomib
Biological: Daratumumab and Hyaluronidase-fihj
Drug: Dexamethasone
Drug: Lenalidomide
Other: Quality-of-Life Assessment

First Posted Date: 2020-09-28

Last Posted Date: 2024-08-09

Lead Sponsor: ECOG-ACRIN Cancer Research Group

Target Recruit Count: 1450

Registration Number: NCT04566328

Locations: 🇺🇸
Columbus Oncology and Hematology Associates Inc, Columbus, Ohio, United States
🇺🇸
Riverside Methodist Hospital, Columbus, Ohio, United States
🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States

and more 592 locations