Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
Isatuximab in Combination With Novel Agents in RRMM - Master Protocol
- Conditions
- Plasma Cell Myeloma Refractory
- Interventions
- First Posted Date
- 2020-11-24
- Last Posted Date
- 2024-07-05
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 197
- Registration Number
- NCT04643002
- Locations
- 🇮🇱
Investigational Site Number : 3760002, Jerusalem, Israel
🇫🇷Investigational Site Number : 2500002, Lille, France
🇫🇷Investigational Site Number : 2500001, Nantes, France
Adaptive COVID-19 Treatment Trial 4 (ACTT-4)
- Conditions
- COVID-19
- Interventions
- First Posted Date
- 2020-11-23
- Last Posted Date
- 2022-06-28
- Lead Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Target Recruit Count
- 1010
- Registration Number
- NCT04640168
- Locations
- 🇺🇸
Cedars Sinai Medical Center, West Hollywood, California, United States
🇺🇸University of California Los Angeles Medical Center - Westwood Clinic, Los Angeles, California, United States
🇺🇸University of Illinois at Chicago College of Medicine - Division of Infectious Diseases, Chicago, Illinois, United States
First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1)
- Conditions
- Hodgkin Lymphoma, Adult
- Interventions
- First Posted Date
- 2020-11-20
- Last Posted Date
- 2022-11-01
- Lead Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
- Target Recruit Count
- 300
- Registration Number
- NCT04638790
- Locations
- 🇮🇳
Tata Memorial Hospital, Mumbai, OPD-81 Main building, Dr. E Borges Road, Parel 400012, India
🇷🇺The Federal Budget-Funded Institution National Medical Surgical Center named after N. I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russian Federation
Methylprednisolone vs. Dexamethasone in COVID-19 Pneumonia (MEDEAS RCT)
- Conditions
- Covid19Viral Pneumonia Human CoronavirusSevere Acute Respiratory Syndrome
- Interventions
- First Posted Date
- 2020-11-19
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- University of Trieste
- Target Recruit Count
- 690
- Registration Number
- NCT04636671
- Locations
- 🇮🇹
Marco Confalonieri, Trieste, TS, Italy
Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2020-11-19
- Last Posted Date
- 2024-07-09
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 28
- Registration Number
- NCT04635189
- Locations
- 🇺🇸
University of Rochester Medical Center, Rochester, New York, United States
Implementation of Adjuvants in Intercostal Nerve Blockades for Thoracoscopic Surgery in Pulmonary Cancer Patients
- Conditions
- Lung CancerPostoperative PainThoracoscopic SurgeryNerve BlockLocal AnesthesiaVideo Assisted Thoracoscopic Surgery
- Interventions
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2021-07-01
- Lead Sponsor
- Jannie Bisgaard Stæhr
- Target Recruit Count
- 45
- Registration Number
- NCT04633850
- Locations
- 🇩🇰
Aalborg University Hospital, Aalborg, Region Of Northern Jutland, Denmark
The Effect of IV Dexamethasone on the Duration of Analgesia of Spinal Anaesthesia for C-Sections at a Jamaican Hospital
- First Posted Date
- 2020-11-10
- Last Posted Date
- 2020-11-10
- Lead Sponsor
- The University of The West Indies
- Target Recruit Count
- 60
- Registration Number
- NCT04624360
- Locations
- 🇯🇲
Victoria Jubilee Hospital, Kingston, Non-US/Canada, Jamaica
Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
- Conditions
- Perioperative Optimization
- Interventions
- Drug: Neuraxial AnalgesiaDrug: PerphenazineDrug: Ondansetron 4 MGDrug: AprepitantDrug: DimenhydrinateDrug: Dexamethasone
- First Posted Date
- 2020-10-28
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- Jennifer Holder-Murray
- Target Recruit Count
- 2500
- Registration Number
- NCT04606264
- Locations
- 🇺🇸
UPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸UPMC Presbyterian, Pittsburgh, Pennsylvania, United States
🇺🇸UPMC Passavant, Pittsburgh, Pennsylvania, United States
Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)
- Conditions
- KeloidHypertrophic ScarScarsScarring
- Interventions
- First Posted Date
- 2020-10-20
- Last Posted Date
- 2020-10-20
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 40
- Registration Number
- NCT04593706
Romiplostim, Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia
- Conditions
- Immune ThrombocytopeniaThrombotic Thrombocytopenic Purpura
- Interventions
- First Posted Date
- 2020-10-19
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- David Gomez Almaguer
- Target Recruit Count
- 12
- Registration Number
- NCT04588194
- Locations
- 🇲🇽
Servicio de Hematología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
Drug Development Updates
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