Dexamethasone
- Generic Name
- Dexamethasone
- Brand Names
- Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper
- Drug Type
- Small Molecule
- Chemical Formula
- C22H29FO5
- CAS Number
- 50-02-2
- Unique Ingredient Identifier
- 7S5I7G3JQL
- Background
Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.
Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.
- Indication
Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes
- Associated Therapies
- -
CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma
- Conditions
- Refractory Multiple MyelomaRecurrent Multiple Myeloma
- Interventions
- First Posted Date
- 2019-01-10
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 36
- Registration Number
- NCT03798678
- Locations
- 🇺🇸
Yale University, New Haven, Connecticut, United States
🇺🇸Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
🇺🇸Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Ruxolitinib Combined With Dexamethasone for HLH
- Conditions
- Hemophagocytic Lymphohistiocytosis
- Interventions
- First Posted Date
- 2019-01-08
- Last Posted Date
- 2019-01-08
- Lead Sponsor
- Capital Research Institute of Pediatrics
- Target Recruit Count
- 50
- Registration Number
- NCT03795909
- Locations
- 🇨🇳
Yan Yue, Beijing, China
Lenalidomide, Rituximab, Gemcitabine, Oxaliplatin and Dexamethasone in Relapse and Refractory DLBCL
- Conditions
- Diffuse Large B-cell Lymphoma RecurrentDiffuse Large B Cell Lymphoma Refractory
- Interventions
- First Posted Date
- 2019-01-07
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Target Recruit Count
- 12
- Registration Number
- NCT03795571
- Locations
- 🇨🇳
The first Affiliated Hospital Of Nanjing Medical University(JiangSu Province Hospital, Nanjing, Jiangsu, China
A Study of Venetoclax Plus Lenalidomide and Dexamethasone for the Treatment of Newly Diagnosed t(11;14)-Positive Multiple Myeloma in Subjects Who Are Ineligible for High-Dose Therapy
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2018-12-24
- Last Posted Date
- 2019-08-28
- Lead Sponsor
- AbbVie
- Registration Number
- NCT03785184
- Locations
- 🇦🇺
St. Vincents Hosp Melbourne /ID# 210266, Fitzroy, Victoria, Australia
🇨🇦Hopital Maisonneuver-Rosemont /ID# 208550, Montreal, Quebec, Canada
🇦🇺Austin Hospital /ID# 210268, Heidelberg, Victoria, Australia
LCI-HEM-MYE-CRD-004 (MMRC-073 CARJAK): Study of CRD for Carfilzomib-Refractory Multiple Myeloma
- Conditions
- Multiple Myeloma
- Interventions
- First Posted Date
- 2018-12-12
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 12
- Registration Number
- NCT03773107
- Locations
- 🇺🇸
Karmanos Cancer Institute, Detroit, Michigan, United States
🇺🇸Levine Cancer Institute, Charlotte, North Carolina, United States
Role of Dexamethasone for Erector Spinae Plane Block in Patients Undergoing Total Abdominal Hysterectomy
- Conditions
- Postoperative Pain
- Interventions
- First Posted Date
- 2018-12-10
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT03769818
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Role of Dexamethasone in Transversus Abdominis Plane Block After Cesarean Section
- Conditions
- Cesarean Section
- Interventions
- First Posted Date
- 2018-12-07
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT03767920
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia
- Conditions
- Relapsed or Refractory Acute Myeloid Leukemia
- Interventions
- First Posted Date
- 2018-12-05
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- University Hospital, Toulouse
- Target Recruit Count
- 142
- Registration Number
- NCT03765541
- Locations
- 🇫🇷
Institut Paoli Calmettes, Marseille, France
🇫🇷CHU de Limoges, Limoges, France
🇫🇷CHU de Bordeaux, Pessac, France
High-Dose Steroid for Knee Arthroplasty Patients Expected to Have Postoperative Pain
- Conditions
- Postoperative PainPostoperative Nausea and VomitingKnee OsteoarthritisPerioperative/Postoperative ComplicationsSurgeryOpioid UseCatastrophizing PainChronic Pain
- Interventions
- First Posted Date
- 2018-12-04
- Last Posted Date
- 2021-06-30
- Lead Sponsor
- Copenhagen University Hospital, Hvidovre
- Target Recruit Count
- 88
- Registration Number
- NCT03763734
- Locations
- 🇩🇰
Hvidovre Hospital, Capital Region of Denmark., Hvidovre, Denmark
🇩🇰Vejle Sygehus, Vejle, Denmark
High-Dose Steroid for Hip Arthroplasty Patients Expected to Have Postoperative Pain
- Conditions
- Opioid UseChronic PainHip OsteoarthritisPerioperative/Postoperative ComplicationsCatastrophizing PainPostoperative PainPostoperative Nausea and VomitingSurgery
- Interventions
- First Posted Date
- 2018-12-04
- Last Posted Date
- 2021-06-30
- Lead Sponsor
- Copenhagen University Hospital, Hvidovre
- Target Recruit Count
- 160
- Registration Number
- NCT03763760
- Locations
- 🇩🇰
Hvidovre Hospital, Capital Region of Denmark., Hvidovre, Denmark
🇩🇰Vejle Sygehus, Vejle, Denmark
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.