Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Dexamethasone Prevention for Patients of Ovarian Hyperstimulation Syndrome

Phase 2

Conditions: Ovarian Hyperstimulation Syndrome

Interventions: Drug: bromocriptine
Drug: dexamethasone

First Posted Date: 2016-07-27

Last Posted Date: 2016-07-27

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 200

Registration Number: NCT02846493

Locations: 🇨🇳
The Sixth Affiliated Hospital,Sun Yat-Sen University, Guangzhou, Guangdong, China

Regulation of Insulin Secretion by the GLP-1 Receptor

Phase 4

Terminated

Conditions: Insulin Secretion

Interventions: Drug: Dexamethasone
Drug: Exendin (9-39)
Other: Hyperglycemic Clamp

First Posted Date: 2016-07-26

Last Posted Date: 2024-12-12

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 6

Registration Number: NCT02844907

Locations: 🇺🇸
Durham VA Medical Center, Durham, NC, Durham, North Carolina, United States

Elotuzumab, Lenalidomide and Dexamethasone in Treatment of Transplant-Eligible Newly Diagnosed Multiple Myeloma Patients

Phase 2

Completed

Conditions: Multiple Myeloma

Interventions: Drug: elotuzumab
Drug: Lenalidomide
Drug: Dexamethasone
Procedure: autologous stem cell transplantation

First Posted Date: 2016-07-25

Last Posted Date: 2023-12-05

Lead Sponsor: SCRI Development Innovations, LLC

Target Recruit Count: 53

Registration Number: NCT02843074

Locations: 🇺🇸
HCA Midwest Health/Research Medical Center, Kansas City, Missouri, United States
🇺🇸
Colorado Blood Cancer Institute, Denver, Colorado, United States
🇺🇸
Nebraska Methodist Hospital, Omaha, Nebraska, United States

and more 2 locations

Rituximab, Eltrombopag and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

Phase 2

Conditions: Immune Thrombocytopenia

Interventions: Drug: Rituximab
Drug: Eltrombopag
Drug: Dexamethasone

First Posted Date: 2016-07-15

Last Posted Date: 2016-07-15

Lead Sponsor: Hospital Universitario Dr. Jose E. Gonzalez

Target Recruit Count: 15

Registration Number: NCT02834286

Locations: 🇲🇽
Servicio de Hematología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico

Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study

Phase 2

Completed

Conditions: Keratoconus
Fuchs' Endothelial Dystrophy
Congenital Hereditary Stromal Dystrophy of the Cornea

Interventions: Drug: Dexamethasone implant OZURDEX

First Posted Date: 2016-07-15

Last Posted Date: 2019-08-16

Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Target Recruit Count: 14

Registration Number: NCT02834260

Locations: 🇫🇷
CHU de Saint Etienne, Saint Etienne, France

Epidural Dexamethasone Versus Betamethasone for Treatment of Lumbosacral Radiculalgia

Phase 4

Conditions: Chronic Pain

Interventions: Drug: Betamethasone
Drug: Dexamethasone

First Posted Date: 2016-07-14

Last Posted Date: 2016-10-25

Lead Sponsor: Basque Health Service

Target Recruit Count: 320

Registration Number: NCT02833116

Locations: 🇪🇸
Enrique Barez, Vitoria-Gasteiz, Álava, Spain

A Study to Test the Combination of Selinexor (KPT-330), Ixazomib, and Dexamethasone in Patients With Myeloma

Phase 1

Completed

Conditions: Multiple Myeloma
Relapsed and/or Refractory Multiple Myeloma

Interventions: Drug: Selinexor
Drug: Ixazomib
Drug: Dexamethasone

First Posted Date: 2016-07-13

Last Posted Date: 2020-11-24

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 18

Registration Number: NCT02831686

Locations: 🇺🇸
Memoral Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States
🇺🇸
Memorial Sloan Kettering Nassau, Uniondale, New York, United States

and more 4 locations

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

Phase 2

Active, not recruiting

Conditions: B Acute Lymphoblastic Leukemia
Mixed Phenotype Acute Leukemia
Acute Leukemia of Ambiguous Lineage

Interventions: Drug: Azacitidine
Procedure: Biospecimen Collection
Procedure: Computed Tomography
Drug: Cyclophosphamide
Drug: Cytarabine
Drug: Daunorubicin
Drug: Daunorubicin Hydrochloride
Drug: Dexamethasone
Procedure: Echocardiography
Drug: Hydrocortisone Sodium Succinate
Drug: Leucovorin
Drug: Leucovorin Calcium
Procedure: Magnetic Resonance Imaging
Drug: Mercaptopurine
Drug: Methotrexate
Procedure: Multigated Acquisition Scan
Drug: Pegaspargase
Drug: Prednisolone
Drug: Thioguanine
Drug: Vincristine
Drug: Vincristine Sulfate

First Posted Date: 2016-07-11

Last Posted Date: 2024-12-27

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 78

Registration Number: NCT02828358

Locations: 🇺🇸
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri, United States
🇺🇸
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States
🇺🇸
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, United States

and more 169 locations