Lamotrigine

Generic Name
Lamotrigine
Brand Names
Lamictal
Drug Type
Small Molecule
Chemical Formula
C9H7Cl2N5
CAS Number
84057-84-1
Unique Ingredient Identifier
U3H27498KS
Background

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 cou...

Indication

Lamotrigine is indicated as adjunctive therapy for the following seizure types in patients ≥2 years of age: partial seizures, primary generalized tonic-clonic seizures, and generalized seizures due to Lennox-Gastaut syndrome.
...

Associated Conditions
Bipolar 1 Disorder, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Seizures, Generalized
Associated Therapies
Conversion to monotherapy
Clinical Trials
Related News

Lithium Versus Lamotrigine in Bipolar Disorder, Type II

Phase 4
Recruiting
Conditions
Bipolar II Disorder
Interventions
Drug: Lithium Carbonate
Drug: Lamotrigine
First Posted Date
2023-12-28
Last Posted Date
2024-06-07
Lead Sponsor
Mental Health Services in the Capital Region, Denmark
Target Recruit Count
200
Registration Number
NCT06184581
Locations
🇩🇰

Psychiatric Center Copenhagen, Copenhagen, Denmark

Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study

First Posted Date
2023-05-31
Last Posted Date
2024-07-30
Lead Sponsor
Assiut University
Target Recruit Count
50
Registration Number
NCT05881928

The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children

First Posted Date
2023-01-26
Last Posted Date
2023-01-26
Lead Sponsor
Dr Cipto Mangunkusumo General Hospital
Target Recruit Count
100
Registration Number
NCT05697614
Locations
🇮🇩

Cipto Mangunkusumo Hospital, Jakarta Pusat, Jakarta, Indonesia

🇮🇩

Harapan Kita Hospital, Jakarta, Indonesia

🇮🇩

Fatmawati Hospital, Jakarta, Indonesia

Treatment of Myotonia - Lamotrigine Versus Namuscla

Not Applicable
Recruiting
Conditions
Non-Dystrophic Myotonia
Interventions
Drug: Lamotrigine
Drug: Namuscla
First Posted Date
2022-12-06
Last Posted Date
2022-12-06
Lead Sponsor
Grete Andersen, MD
Target Recruit Count
32
Registration Number
NCT05639257
Locations
🇩🇰

Copenhagen Neuromuscular Center, department of Neurology, Rigshospitalet, Copenhagen, Denmark

Physiological-based Pharmacokinetics Approach to Medication Exposure During Pregnancy and Breastfeeding

First Posted Date
2022-07-11
Last Posted Date
2024-08-21
Lead Sponsor
Page B. Pennell, MD
Target Recruit Count
60
Registration Number
NCT05450978
Locations
🇺🇸

Kaufmann Medical Building, Pittsburgh, Pennsylvania, United States

Enhancing the Effects of Alcohol Treatment With Lamotrigine

Phase 2
Completed
Conditions
Alcohol Use Disorder
Interventions
Drug: Placebo
Drug: Lamotrigine
First Posted Date
2021-02-25
Last Posted Date
2024-12-05
Lead Sponsor
Brown University
Target Recruit Count
44
Registration Number
NCT04770493
Locations
🇺🇸

Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island, United States

A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

First Posted Date
2020-10-26
Last Posted Date
2024-03-12
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
40
Registration Number
NCT04602221
Locations
🇺🇸

Hassman Research Institute, Marlton, New Jersey, United States

🇺🇸

Collaborative Neuroscience Research, LLC, Long Beach, California, United States

The Effect of a Single Dose of Lamotrigine on Brain Function in Healthy Volunteers

Not Applicable
Completed
Conditions
Healthy
Interventions
Drug: Lamotrigine
Drug: Placebos
First Posted Date
2020-05-21
Last Posted Date
2020-05-21
Lead Sponsor
University of Oxford
Target Recruit Count
36
Registration Number
NCT04396938
Locations
🇬🇧

University of Oxford, Oxford, Oxfordshire, United Kingdom

Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine

First Posted Date
2019-11-07
Last Posted Date
2021-03-29
Lead Sponsor
Charite University, Berlin, Germany
Target Recruit Count
75
Registration Number
NCT04156035
Locations
🇩🇪

Medical School Berlin, Berlin, Germany

A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults

Phase 1
Completed
Conditions
Healthy Participants
Interventions
Drug: AG-881
Drug: Lamotrigine
First Posted Date
2019-07-11
Last Posted Date
2019-10-14
Lead Sponsor
Agios Pharmaceuticals, Inc.
Target Recruit Count
22
Registration Number
NCT04015687
Locations
🇺🇸

Celerion, Inc, Tempe, Arizona, United States

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