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Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated logo
🇺🇸United States
Ownership
Public
Established
1989-01-01
Employees
5.4K
Market Cap
$123.9B
Website
http://www.vrtx.com

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

Phase 2
Recruiting
Conditions
Proteinuric Kidney Disease
Interventions
Drug: Placebo
First Posted Date
2022-04-06
Last Posted Date
2025-06-24
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
466
Registration Number
NCT05312879
Locations
🇺🇸

Alabama Kidney Research, Alabaster, Alabama, United States

🇺🇸

EmVenio Research, Chicago, Illinois, United States

🇺🇸

Cardiology, P.C., Birmingham, Alabama, United States

and more 309 locations

Evaluation of Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis Subjects Without an F508del Mutation

Phase 3
Completed
Conditions
Cystic Fibrosis
Interventions
Other: Placebo (matched to ELX/TEZ/IVA)
Other: Placebo (matched to IVA)
Drug: IVA
First Posted Date
2022-03-10
Last Posted Date
2024-08-01
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
307
Registration Number
NCT05274269
Locations
🇦🇹

Medizinische Universität Innsbruck, Innsbruck, Austria

🇧🇪

Cliniques Universitaires de Bruxelles Hopital Erasme, Brussels, Belgium

🇧🇪

Universitair Ziekenhuis Brussel - Campus Jette, Brussels, Belgium

and more 87 locations

Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older

Phase 3
Active, not recruiting
Conditions
Cystic Fibrosis
Interventions
First Posted Date
2021-12-10
Last Posted Date
2025-03-13
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
71
Registration Number
NCT05153317
Locations
🇺🇸

Banner University of Arizona Medical Center, Tucson, Arizona, United States

🇺🇸

Stanford University, Palo Alto, California, United States

🇺🇸

Children's Hospital of Colorado, Aurora, Colorado, United States

and more 19 locations

A Study Evaluating the Safety of Elexacaftor/Tezacaftor/Ivacaftor in Participants With Cystic Fibrosis (CF)

Phase 3
Completed
Conditions
Cystic Fibrosis
Interventions
First Posted Date
2021-11-08
Last Posted Date
2023-07-11
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
86
Registration Number
NCT05111145
Locations
🇦🇺

The Prince Charles Hospital, Chermside, Australia

🇦🇺

Alfred Hospital, Melbourne, Australia

🇦🇺

Institute for Respiratory Health, Nedlands, Australia

and more 21 locations

A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

Phase 3
Completed
Conditions
Cystic Fibrosis
Interventions
Drug: IVA
Drug: Placebo (matched to ELX/TEZ/IVA)
Drug: Placebo (matched to VX-121/TEZ/D-IVA)
Drug: Placebo (matched to IVA)
First Posted Date
2021-10-13
Last Posted Date
2024-06-13
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
597
Registration Number
NCT05076149
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

Banner University of Arizona Medical Center, Tucson, Arizona, United States

🇺🇸

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

and more 167 locations

A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty

Phase 2
Completed
Conditions
Acute Pain
Interventions
Drug: Placebo (matched to VX-548)
Drug: HB/APAP
Drug: Placebo (matched to HB/APAP)
First Posted Date
2021-09-05
Last Posted Date
2024-12-27
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
303
Registration Number
NCT05034952
Locations
🇺🇸

Arizona Research Center, Phoenix, Arizona, United States

🇺🇸

Lotus Clinical Research, Pasadena, California, United States

🇺🇸

Chesapeake Research Group, Pasadena, Maryland, United States

and more 4 locations

A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF)

Phase 3
Completed
Conditions
Cystic Fibrosis
Interventions
Drug: IVA
Drug: Placebo (matched to ELX/TEZ/IVA)
Drug: Placebo (matched to VX-121/TEZ/D-IVA)
Drug: Placebo (matched to IVA)
First Posted Date
2021-09-02
Last Posted Date
2024-10-03
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
435
Registration Number
NCT05033080
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

Banner University of Arizona Medical Center, Tucson, Arizona, United States

🇺🇸

Arkansas Children's Hospital, Little Rock, Arkansas, United States

and more 136 locations

A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

Phase 2
Completed
Conditions
Acute Pain
Interventions
Drug: Placebo (matched to VX-548)
Drug: HB/APAP
Drug: Placebo (matched to HB/APAP)
First Posted Date
2021-07-26
Last Posted Date
2025-06-25
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
274
Registration Number
NCT04977336
Locations
🇺🇸

Shoals Medical Trials Inc., Sheffield, Alabama, United States

🇺🇸

Arizona Research Center, Phoenix, Arizona, United States

🇺🇸

Anaheim Clinical Trials, Anaheim, California, United States

and more 9 locations

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

Phase 3
Completed
Conditions
Cystic Fibrosis
Interventions
First Posted Date
2021-07-20
Last Posted Date
2023-10-03
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
82
Registration Number
NCT04969224
Locations
🇦🇺

Royal Adelaide Hospital, Adelaide, Australia

🇦🇺

The Prince Charles Hospital, Chermside, Australia

🇦🇺

Alfred Hospital, Melbourne, VIC, Australia

and more 16 locations

A Decentralized Study to Evaluate Physical Activity and Cough Frequency Using Wearable Technology in Cystic Fibrosis

Completed
Conditions
Cystic Fibrosis
First Posted Date
2021-06-11
Last Posted Date
2022-01-19
Lead Sponsor
Vertex Pharmaceuticals Incorporated
Target Recruit Count
51
Registration Number
NCT04923464
Locations
🇺🇸

National Jewish Health, Denver, Colorado, United States

🇺🇸

Yale New Haven Hospital, New Haven, Connecticut, United States

🇺🇸

Central Florida Pulmonary Group, P.A., Orlando, Florida, United States

and more 14 locations
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