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EMD SERONO RESEARCH & DEVELOPMENT INSTITUTE, INC.

🇺🇸United States
Ownership
Subsidiary
Employees
-
Market Cap
-
Website

Phase 1 Trial of MSC2490484A, an Inhibitor of a DNA-dependent Protein Kinase, in Combination With Radiotherapy

Phase 1
Completed
Conditions
Advanced Solid Tumors
Interventions
Drug: M3814 100 mg
Drug: M3814 200 mg
Drug: M3814 300 mg
Drug: M3814 400 mg
Drug: M3814 50 mg
Radiation: Fractionated RT
First Posted Date
2015-08-06
Last Posted Date
2024-10-11
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
52
Registration Number
NCT02516813
Locations
🇳🇴

Research site, Oslo, Norway

🇺🇸

Holy Cross Hospital Inc., Fort Lauderdale, Florida, United States

🇺🇸

University of Miami Miller School of Medicine, Miami, Florida, United States

and more 16 locations

Avelumab in Non-Small Cell Lung Cancer (JAVELIN Lung 200)

Phase 3
Completed
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
First Posted Date
2015-03-20
Last Posted Date
2020-08-03
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
792
Registration Number
NCT02395172
Locations
🇺🇸

University of Alabama, Tuscaloosa, Alabama, United States

🇺🇸

Mayo Clinic, Scottsdale , Phoenix, Arizona, United States

🇺🇸

Pacific Cancer Medical Center, Inc., Anaheim, California, United States

and more 256 locations

First in Human Study of M4344 in Participants With Advanced Solid Tumors

Phase 1
Completed
Conditions
Solid Tumor
Advanced Solid Tumor
Interventions
Drug: M4344 40 mg BIW
Drug: M4344 100 mg BID
Drug: M4344 150 mg QD
Drug: M4344 350 mg QD
Drug: M4344 10 mg BIW
Drug: M4344 20 mg BIW
Drug: M4344 160 mg BIW
Drug: M4344 1200 mg BIW
Drug: M4344 700 mg BIW
Drug: M4344 80 mg BIW
Drug: M4344 1050 mg BIW
Drug: M4344 300 mg BIW
Drug: M4344 450 mg BIW
Drug: M4344 250 mg QD
Drug: M4344 400 mg
Drug: M4344 500 mg
First Posted Date
2014-10-29
Last Posted Date
2023-03-16
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
97
Registration Number
NCT02278250
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

🇺🇸

Washington University in St. Louis, Saint Louis, Missouri, United States

and more 13 locations

M6620 First in Human Study

First Posted Date
2014-06-06
Last Posted Date
2020-04-01
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
200
Registration Number
NCT02157792
Locations
🇺🇸

Mayo Clinic Arizona, Phoenix, Arizona, United States

🇺🇸

Sharp Memorial Hospital, San Diego, California, United States

🇺🇸

Rocky Mountain Cancer Centers, LLP, Denver, Colorado, United States

and more 27 locations

Avelumab in Participants With Merkel Cell Carcinoma (JAVELIN Merkel 200)

Phase 2
Completed
Conditions
Carcinoma, Merkel Cell
Interventions
First Posted Date
2014-06-04
Last Posted Date
2024-03-13
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
204
Registration Number
NCT02155647
Locations
🇺🇸

UCLA Medical Center, Los Angeles, California, United States

🇺🇸

The Angeles Clinic and Research Institute - West LA, Los Angeles, California, United States

🇺🇸

University of Colorado, Aurora, Colorado, United States

and more 58 locations

A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee

Phase 2
Completed
Conditions
Osteoarthritis, Knee
Interventions
Drug: Placebo
First Posted Date
2013-08-08
Last Posted Date
2020-07-13
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
549
Registration Number
NCT01919164
Locations
🇷🇴

Research site, Bucharest, Romania

🇭🇰

Research Site, Hong Kong, Hong Kong

Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)

Phase 1
Completed
Conditions
Solid Tumors
Interventions
First Posted Date
2013-01-21
Last Posted Date
2021-12-20
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
1756
Registration Number
NCT01772004
Locations
🇺🇸

Cancer Treatment Centers of America - Western Regional Medical Center, Goodyear, Arizona, United States

🇺🇸

Scottsdale Healthcare Corporation, Scottsdale, Arizona, United States

🇺🇸

Pinnacle Oncology Hematology, Scottsdale, Arizona, United States

and more 71 locations

Oral Cladribine in Early Multiple Sclerosis (MS)

Phase 3
Completed
Conditions
Multiple Sclerosis
Interventions
First Posted Date
2008-07-31
Last Posted Date
2021-03-22
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
617
Registration Number
NCT00725985
Locations
🇺🇸

Hope Research Institute Medical Plaza LLC Desert Hills, Phoenix, Arizona, United States

🇺🇸

Multiple Sclerosis Center Drive, Neurology Suite 701, Newport Beach, California, United States

🇺🇸

University of Colorado at Denver Health Sciences, Denver, Colorado, United States

and more 154 locations

CLARITY Extension Study

Phase 3
Completed
Conditions
Relapsing-Remitting Multiple Sclerosis
Interventions
Drug: Placebo
First Posted Date
2008-03-24
Last Posted Date
2020-12-07
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
867
Registration Number
NCT00641537
Locations
🇬🇧

Research Site, Stoke-on-Trent, United Kingdom

🇷🇺

Reseach Site, Saratov, Russian Federation

A Phase 2 Study of Cladribine Add-on to Interferon-beta (IFN-beta) Therapy in Multiple Sclerosis (MS) Subjects With Active Disease (ONWARD)

Phase 2
Completed
Conditions
Multiple Sclerosis
Interventions
First Posted Date
2007-02-19
Last Posted Date
2020-10-12
Lead Sponsor
EMD Serono Research & Development Institute, Inc.
Target Recruit Count
172
Registration Number
NCT00436826
Locations
🇪🇸

Research Site, Seville, Spain

🇪🇸

Research site, Barcelona, Spain

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