JOHN HOPE FRANKLIN CENTER

🇺🇸United States

Country: 🇺🇸United States

Ownership: Private

Established: 1838-01-01

Employees: 5K

Market Cap: -

Website: http://www.duke.edu

Clinical Trials

Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure

Phase 2

Completed

Conditions: Heart Failure

Interventions: Drug: Spironolactone
Drug: Placebo

First Posted Date: 2014-09-09

Last Posted Date: 2017-06-14

Lead Sponsor: Duke University

Target Recruit Count: 360

Registration Number: NCT02235077

Locations: 🇺🇸
Southeastern Regional Medical Center, Lumberton, North Carolina, United States
🇺🇸
Metro Health System, Cleveland, Ohio, United States
🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

and more 19 locations

Molecular Mechanisms Underlying Prostate Cancer Disparities

Completed

Conditions: Prostate Cancer

Interventions: Device: Biopsy or prostatectomy

First Posted Date: 2014-09-01

Last Posted Date: 2020-11-13

Lead Sponsor: Duke University

Target Recruit Count: 226

Registration Number: NCT02229565

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Treatment for Teens With Alcohol Abuse and Depression

Not Applicable

Completed

Conditions: AOD Use, Abuse, and Dependence
Depression

Interventions: Behavioral: MET/CBT-12
Behavioral: CBT-D
Other: D-TAU

First Posted Date: 2014-08-28

Last Posted Date: 2020-02-05

Lead Sponsor: Duke University

Target Recruit Count: 103

Registration Number: NCT02227589

Locations: 🇺🇸
University of Connecticut Health Center, Farmington, Connecticut, United States
🇺🇸
Duke Child and Family Study Center, Durham, North Carolina, United States

Improving the Health of South African Women With Traumatic Stress in HIV Care (C0147)

Not Applicable

Completed

Conditions: Trauma Exposure
HIV

Interventions: Behavioral: Improving AIDS Care after Trauma (ImpACT)

First Posted Date: 2014-08-22

Last Posted Date: 2024-07-24

Lead Sponsor: Duke University

Target Recruit Count: 64

Registration Number: NCT02223390

Locations: 🇿🇦
University of Cape Town, Cape Town, South Africa

Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease

Phase 4

Completed

Conditions: Sickle Cell Disease

Interventions: Drug: Hydromorphone (Patient Specific dosing)
Drug: Hydromorphone (Standardized, weight-based dosing)
Drug: Morphine Sulfate (Standardized, weight-based dosing)
Drug: Morphine Sulfate (Patient Specific dosing)

First Posted Date: 2014-08-21

Last Posted Date: 2017-08-04

Lead Sponsor: Duke University

Target Recruit Count: 106

Registration Number: NCT02222246

Locations: 🇺🇸
Mount Sinai Hospital, New York, New York, United States
🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States

BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia

Completed

Conditions: Invasive Candidiasis

First Posted Date: 2014-08-20

Last Posted Date: 2022-02-28

Lead Sponsor: Duke University

Target Recruit Count: 515

Registration Number: NCT02220790

Locations: 🇺🇸
Ann and Robert Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
🇺🇸
Cleveland Clinic Children's, Cleveland, Ohio, United States
🇺🇸
Texas Children's Hospital, Houston, Texas, United States

and more 19 locations

Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a

Phase 2

Completed

Conditions: ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)

Interventions: Drug: CERC-501
Drug: placebo

First Posted Date: 2014-08-18

Last Posted Date: 2019-01-08

Lead Sponsor: Duke University

Target Recruit Count: 163

Registration Number: NCT02218736

Locations: 🇺🇸
CaseWestern Reserve University, Cleveland, Ohio, United States
🇺🇸
Andrew Goddard, MD, Indianapolis, Indiana, United States
🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

and more 3 locations

Improving Memory Performance by Applying Cognitive Training

Not Applicable

Completed

Conditions: HIV

Interventions: Device: Active Cognitive Training (ACT)
Device: Control (CON)

First Posted Date: 2014-08-15

Last Posted Date: 2017-06-28

Lead Sponsor: Duke University

Target Recruit Count: 33

Registration Number: NCT02216591

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Medical Home Care for Hematopoietic Stem Cell Transplantation Phase 2

Not Applicable

Terminated

Conditions: Blood Disorders

Interventions: Other: Patient-Centered Medical Home (PCMH)
Other: Standard Care

First Posted Date: 2014-08-15

Last Posted Date: 2024-11-11

Lead Sponsor: Duke University

Target Recruit Count: 61

Registration Number: NCT02218151

Locations: 🇺🇸
Duke University Adult Bone Marrow Transplant Clinic, Durham, North Carolina, United States

The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine

Not Applicable

Completed

Conditions: Fever

Interventions: Other: Acetaminophen Arm
Other: Placebo Arm
Other: Ibuprofen Arm

First Posted Date: 2014-08-11

Last Posted Date: 2018-02-07

Lead Sponsor: Duke University

Target Recruit Count: 104

Registration Number: NCT02212990

Locations: 🇺🇸
Duke University Health System, Durham, North Carolina, United States

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