A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
- Conditions
- Basal Ganglia GerminomaDiabetes InsipidusThalamic GerminomaCentral Nervous System GerminomaPineal Region GerminomaSuprasellar Germinoma
- Interventions
- Radiation: 3-Dimensional Conformal Radiation TherapyProcedure: Biospecimen CollectionRadiation: Intensity-Modulated Radiation TherapyProcedure: Lumbar PunctureProcedure: Magnetic Resonance ImagingOther: Questionnaire AdministrationProcedure: Surgical Procedure
- First Posted Date
- 2024-04-16
- Last Posted Date
- 2025-06-11
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 240
- Registration Number
- NCT06368817
- Locations
- πΊπΈ
USA Health Strada Patient Care Center, Mobile, Alabama, United States
πΊπΈArkansas Children's Hospital, Little Rock, Arkansas, United States
πΊπΈLoma Linda University Medical Center, Loma Linda, California, United States
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
- Conditions
- Recurrent Childhood Acute Myeloid LeukemiaRecurrent Childhood Myelodysplastic SyndromeRecurrent Juvenile Myelomonocytic LeukemiaRefractory Childhood Acute Myeloid LeukemiaRefractory Childhood Myelodysplastic SyndromeRefractory Juvenile Myelomonocytic Leukemia
- Interventions
- Procedure: Biospecimen CollectionProcedure: Bone Marrow AspirationProcedure: Bone Marrow BiopsyProcedure: EchocardiographyProcedure: Lumbar Puncture
- First Posted Date
- 2024-02-08
- Last Posted Date
- 2025-02-13
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 36
- Registration Number
- NCT06247787
- Locations
- πΊπΈ
Children's Hospital of Alabama, Birmingham, Alabama, United States
πΊπΈChildren's Hospital of Orange County, Orange, California, United States
πΊπΈUCSF Medical Center-Mission Bay, San Francisco, California, United States
Somatic Mosaicism in Twins Discordant for Childhood Cancer
- Conditions
- Pediatric Central Nervous System TumorDiscordant TwinCentral Nervous System TumorSomatic Mutation
- Interventions
- Other: Biospecimen collectionOther: Questionnaire Administration
- First Posted Date
- 2023-09-26
- Last Posted Date
- 2025-06-26
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 50
- Registration Number
- NCT06054295
- Locations
- πΊπΈ
University of Minnesota, Minneapolis, Minnesota, United States
A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia
- Conditions
- Recurrent Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute LeukemiaRefractory Acute Myeloid Leukemia Due to Lineage Switch From Mixed Phenotype Acute LeukemiaRecurrent Mixed Phenotype Acute LeukemiaRecurrent Acute Leukemia of Ambiguous LineageRecurrent Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-RearrangedRefractory Acute Myeloid Leukemia Due to Lineage Switch From B Acute Lymphoblastic Leukemia, KMT2A-RearrangedRecurrent Acute Lymphoblastic LeukemiaRecurrent Acute Myeloid Leukemia Due to Lineage Switch From Acute Leukemia of Ambiguous LineageRefractory Acute Leukemia of Ambiguous LineageRefractory Acute Lymphoblastic Leukemia
- Interventions
- Procedure: Biospecimen CollectionProcedure: Bone Marrow AspirationProcedure: EchocardiographyProcedure: Lumbar PunctureProcedure: Multigated Acquisition Scan
- First Posted Date
- 2023-03-09
- Last Posted Date
- 2025-06-11
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 78
- Registration Number
- NCT05761171
- Locations
- πΊπΈ
Children's Hospital of Alabama, Birmingham, Alabama, United States
πΊπΈArkansas Children's Hospital, Little Rock, Arkansas, United States
πΊπΈKaiser Permanente Downey Medical Center, Downey, California, United States
A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients
- Conditions
- Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm
- Interventions
- Procedure: Biospecimen Collection
- First Posted Date
- 2023-02-03
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 143
- Registration Number
- NCT05711667
- Locations
- πΊπΈ
UCSF Medical Center-Mission Bay, San Francisco, California, United States
πΊπΈUT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States
πΊπΈChildren's Hospital of Alabama, Birmingham, Alabama, United States
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma
- Conditions
- Cardiovascular DisorderHodgkin LymphomaClonal Hematopoiesis
- Interventions
- Procedure: Biospecimen CollectionOther: Electronic Health Record ReviewProcedure: Magnetic Resonance ImagingOther: Survey Administration
- First Posted Date
- 2023-01-30
- Last Posted Date
- 2025-02-13
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 230
- Registration Number
- NCT05705531
- Locations
- πΊπΈ
USA Health Strada Patient Care Center, Mobile, Alabama, United States
πΊπΈPhoenix Childrens Hospital, Phoenix, Arizona, United States
πΊπΈAlfred I duPont Hospital for Children, Wilmington, Delaware, United States
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
- Conditions
- Myeloid Leukemia Associated With Down SyndromeB Acute Lymphoblastic Leukemia Associated With Down SyndromeDown Syndrome
- Interventions
- Procedure: Biospecimen CollectionOther: Clinical EvaluationOther: Questionnaire AdministrationOther: Survey Administration
- First Posted Date
- 2023-01-27
- Last Posted Date
- 2025-04-17
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 330
- Registration Number
- NCT05702645
- Locations
- πΊπΈ
Valley Children's Hospital, Madera, California, United States
πΊπΈUCSF Benioff Children's Hospital Oakland, Oakland, California, United States
πΊπΈUCSF Medical Center-Mission Bay, San Francisco, California, United States
Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma
- Conditions
- Mixed Phenotype Acute LeukemiaB Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1B Acute Lymphoblastic Leukemia, BCR-ABL1-LikeLymphoblastic LymphomaB Acute Lymphoblastic LeukemiaT Acute Lymphoblastic Leukemia
- Interventions
- Procedure: Biospecimen CollectionDietary Supplement: LevocarnitineOther: Quality-of-Life Assessment
- First Posted Date
- 2022-11-02
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 440
- Registration Number
- NCT05602194
- Locations
- πΊπΈ
Children's Hospital of Alabama, Birmingham, Alabama, United States
πΊπΈProvidence Alaska Medical Center, Anchorage, Alaska, United States
πΊπΈKingman Regional Medical Center, Kingman, Arizona, United States
Molecular Epidemiology of Pediatric Germ Cell Tumors
- Conditions
- Late EffectsEmbryonal CarcinomaPediatric Germ Cell TumorGerm Cell TumorGerminomaTeratomaYolk Sac TumorChoriocarcinomaMixed Germ Cell Tumor
- Interventions
- Other: Questionnaire AdministrationOther: Tumor Specimen CollectionOther: Germline DNA SamplesProcedure: Blood Sample Collection
- First Posted Date
- 2022-10-03
- Last Posted Date
- 2024-09-30
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 1151
- Registration Number
- NCT05564026
- Locations
- πΊπΈ
University of Minnesota, Minneapolis, Minnesota, United States
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
- Conditions
- Group D RetinoblastomaBilateral RetinoblastomaStage I RetinoblastomaUnilateral RetinoblastomaChildhood Intraocular Retinoblastoma
- Interventions
- Procedure: Biospecimen CollectionProcedure: Examination Under AnesthesiaProcedure: Magnetic Resonance ImagingProcedure: Ultrasound Biomicroscopy
- First Posted Date
- 2022-08-17
- Last Posted Date
- 2025-06-12
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 26
- Registration Number
- NCT05504291
- Locations
- πΊπΈ
Children's Hospital of Alabama, Birmingham, Alabama, United States
πΊπΈChildren's Hospital Los Angeles, Los Angeles, California, United States
πΊπΈLucile Packard Children's Hospital Stanford University, Palo Alto, California, United States