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临床试验/NCT02594657
NCT02594657Unknown不适用

Pedal Rate Influence on Oxygen Consumption in Eccentric

University Hospital, Clermont-Ferrand2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2015年8月1日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
15
试验地点
2
主要终点
Oxygen consumption (VO2 ml/min)

研究概览

简要总结

Nowadays, ECC exercise can be realized using various modalities that target small or large muscle masses in a segmentary or dynamic way. The training program proposed in this study is realised on an handmade ergocycle which allows eccentric contractions.

With this type of ergometer, O2 consumption (VO2) is three to five fold lower than during an exercise realised at the same power output with a concentric ergocycle. Due to this later propertie, which origins are not yet fully identified, there is an increasing interest to embed ECC in rehabilitation programs.

The investigators hypothesis that a higher pedal rate will induce a lower oxygen consumption, with the same benefits.

This study aims to compare oxygen consumption at two pedal rates : 50 and 80 rotation per minute (rpm).

The ultimate goal is to assess efficacy and tolerance of eccentric training on ergocycle and to enhance comprehension of the physiological mecanisms involved in the lower O2 consumption observed.

详细描述

The training program proposed in this study is realised on an handmade ergocycle which allows almost pur eccentric contractions.

Fifteen healthy volunteers realize a incremental test until exertion on a concentric ergometer. If the minimal power output of 200W is reached, the volunteers are familiarized with eccentric exercise during several bouts of exercise. This habituation session allows avoiding the secondary muscular effects of high intensity eccentric exercise.

Then, volunteers could take part in a two-stepped eccentric protocol: 1) an incremental test consisting in 3 stages. Each stage lasts 4 minutes.

  1. A constant-load test realized at 320W during 6 minutes. Each test is realized twice: at 50 and 80 rpm and sequence is randomly assigned.

[One step (incremental or constant load) = two tests (50 and 80 rpm)]

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
盲法
None

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • physically active
  • Pmax concentric > 200W
  • Pmax > Pmax théo sédentaire

排除标准

  • cardio pulmonary, osteo articulary or muscular diseases
  • Eccentric based physical activities or sports (weight liftering, alpine skiing)

结局指标

主要结局

Oxygen consumption (VO2 ml/min)

时间窗: at day 1

Oxygen consumption (VO2) is continuously assesse during exercises at 50 and 80 rpm.

次要结局

  • muscular oxygen kinetic (arbitrary unit and %)(at day 1)
  • Cardiac output( l/min)(at day 1)
  • Muscular activity (mV)(at day 1 during one and half minute (1min30s))
  • VO2 (ml/min)(at day 1)

研究者

发起方
University Hospital, Clermont-Ferrand
申办方类型
Other
责任方
Sponsor

研究点 (2)

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