Galactose Mediated Glycogen Resynthesis and the Effects on Metabolism During Subsequent Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Muscle glycogen synthesis rates (mmol/kg/dm/h)
研究概览
简要总结
This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.
详细描述
Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.
Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index in the range: 18.5 - 27.5 kg/m2
- •Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
- •Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)
排除标准
- •Lidocaine allergy
- •Current participation in another scientific/clinical study
- •Bleeding disorder/s
- •Current or recent smoker to include vaping (last 60 days)
- •Existence of food intolerances
- •Poor recent health as indicated in the general health questionnaire
- •Engage in uncommon eating practices (e.g. sustained periods of fasting)
- •Diagnosed with galactosemia
结局指标
主要结局
Muscle glycogen synthesis rates (mmol/kg/dm/h)
时间窗: 4 hours
Muscle glycogen synthesis rates over the post-exercise recovery period
次要结局
- Fat oxidation rates (g/min)(Up to 90 minutes)
- Plasma galactose (mmol/L)(Up to 6 hours)
- Plasma glucose (mmol/L)(Up to 6 hours)
- Carbohydrate oxidation rates (g/min)(Up to 90 minutes)
- Plasma non-esterified fatty acids (mmol/L)(Up to 6 hours)
- Plasma glycerol (umol/L)(Up to 6 hours)
- Serum insulin (mU/L)(Up to 6 hours)
- Plasma lactate (mmol/L)(Up to 6 hours)
- Plasma glucagon (pmol/L)(Up to 6 hours)