Applicability of cornea confocal microscopy in the diagnosis of small fiber neuropathy. - Cornea confocal microscopy in small fiber neuropathy.

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 225 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Healthy subjects (n<=20)
•a. Male and female subjects of 18 years or older
•b. One or less positive answers on the SFN-SIQ
•c. Written informed consent;Patients (n<=200):
•Those who are referred to our center for the analysis of possible small fiber neuropathy are eligible for participation in this study.

•Healthy subjects (n=20)
•- Sensory symptoms in hands or feet or known with mono-/polyneuropathy.
•- Known illnesses that can cause neuropathy, like diabetes mellitus, renal failure, alcohol abuse, rheumatoid arthritis, SLE, sarcoidosis, and thyroid dysfunction.
•- History of diseases of the eye such as dry eyes, atopic keratoconjunctivitis, epithelial membrane basement dystrophies, cystic corneal disorders, which all affect corneal innervation.
•- Patients with chronic glycemic exposure since this is a strong risk factor for corneal subbasal nerve loss.
•- Use of medication (also in the past) known to possibly cause polyneuropathy.;Patients (n=200)
•- History of diseases of the eye (such as mentioned above);Participants are excluded from this study when they do not want to be informed about defects or accidental findings which could be found during the pre-screening of the ophthalmologist.

发起方

Medisch Universitair Ziekenhuis Maastricht