Delirium Evaluation With Longitudinal Tau Assessment
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Delirium
研究概览
简要总结
The goal of this observational study is to learn if there are potential digital and plasma-based biomarkers that could help detect, predict, and prognosticate delirium in older adult patients who are admitted to the intensive care unit (ICU). The main question DELTA aims to answer is:
Can digital biometrics predict and detect delirium in older adult ICU patients? Do biomarkers of neurodegeneration fluctuate in ICU patients in such a way that delrium could potentially be predicted?
Participants admitted o the ICU will wear a digital device to collect biometric data and will have serial plasma samples collected during ICU admission and patients will be also assessed for delirium daily by study staff.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to the intensive care unit
- •Able to consent or have a legally authorized representative consent on their behalf
- •English speaker
- •Expected ICU stay of 48 hours or more
排除标准
- •Advanced dementia
- •End stage liver disease
- •Renal replacement therapy
- •Structural brain injury, including but not limited to traumatic brain injury, cerebrovascular accident and intracranial hemorrhage,
结局指标
主要结局
Delirium
时间窗: Between enrollment and ICU discharge, up to a maximum of 10 days.
Delirium incidence as assessed by the CAM-ICU instrument.
次要结局
- Sleep Duration(Between enrollment and ICU discharge up to a maximum 10 days in the ICU.)
- Sleep fragmentation(Nightly between enrollment and ICU discharge, up to a maximum of 10 days.)
- Circadian activity rhythm disruption(Daily between enrollment and ICU discharge, up to a maximum of 10 days.)
研究者
Stuti Jaiswal
Faculty Hospitalist
Scripps Health