Neuromodulation of Conscious Perception: Investigating Thalamic Roles Through Ultrasonic Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Change in Sensitivity Derived From the Signal Detection Theory (SDT)
研究概览
简要总结
The purpose of this study is to evaluate the role that the thalamus (the egg-shaped structure in the middle of your brain) plays in perception using a low-intensity ultrasound pulsation (LIFUP) device. The researchers expect to observe differential changes in the perceptual outcomes based on the LIFUP stimulation of different thalamic areas
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be right-handed.
- •Must have normal or corrected-to-normal vision (while wearing contact lenses). Please note: persons who need eyeglasses to achieve 20/20 vision cannot be included in this study as eyeglasses cannot be worn during the study visit.
- •Must not be on any medications for any neurological, psychological, or psychiatric conditions.
- •Must be English speaking.
- •Must be capable of giving written informed consent.
排除标准
- •Vision that is not 20/20, or vision that is not corrected to 20/20 while wearing contact lenses.
- •Please note: persons needing eyeglasses to achieve 20/20 vision cannot be included in this study as eyeglasses cannot be worn during the study visit.
- •History of significant head injury with loss of consciousness.
- •Learning disability or other developmental disorder.
- •Medication use for any neurological, psychological, or psychiatric conditions.
- •Any impairment (sensory or motor loss), activity, or situation that in the judgment of the study coordinator or Principal Investigators would prevent satisfactory completion of the study protocol.
结局指标
主要结局
Change in Sensitivity Derived From the Signal Detection Theory (SDT)
时间窗: Up to 60 minutes after intervention
SDT was a means of measuring participants' ability to differentiate between information-bearing patterns and random patterns that distract from the information. Sensitivity measured a participant's ability to differentiate between real and scrambled images on a scale from 0.0 to 1.0, with higher scores indicating better accuracy in detecting a signal when it was present and lower scores indicating more missed signals. A score of 1.0 was perfect sensitivity (i.e., never missing a real signal).
Change in Perceptual Criterion Derived From the Signal Detection Theory (SDT)
时间窗: Up to 60 minutes after intervention
SDT was a means of measuring participants' ability to differentiate between information-bearing patterns and random patterns that distract from the information. Perceptual criterion measured a participant's tendency to say "yes" or "no" when the participant was unsure if a signal was present. Perceptual criterion was measured on a scale from -1.0 to 1.0, with a score of 0 indicating no bias towards "yes" or "no". Negative scores meant a bias towards "yes" (more likely to say a signal was present), while positive scores meant a bias towards "no" (more likely to say a signal was absent).
次要结局
未报告次要终点
研究者
Zirui Huang
Research Assistant Professor, Anesthesiology and Research Fellow, Anesthesiology
University of Michigan