Prospective Study : Association Between Pococyturia and Pre-eclampsia Severity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Severity of pre-eclampsia
研究概览
简要总结
Pre-eclampsia is an hypertensive disorder appearing during pregnancy, inducing serious maternal, fetal and neonatal mortality and morbidity. Twenty four hours proteinuria is a key element to define pre-eclampsia severity but is delaying the result by 24 hours and constraining for the patient. A simple and rapid indicator for severe preeclampsia would help clinicians to make appropriate decision in patient management. We hypothesized that urinary podocyturia is correlated to preeclampsia severity. This is a prospective, non-interventional, monocentric study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women aged 18 years or more
- •single pregnancy
- •admission for pre-eclampsia
- •patient receiving information and non-opposition to participate
排除标准
- •multiple pregnancy
- •in utero fetal demise excepted if associated with pre-eclampsia
- •antecedent of nephropathy
- •fetal malformation, chromosomal anomalies
- •inability to understand information provided
- •prisoner or under administrative supervision
结局指标
主要结局
Severity of pre-eclampsia
时间窗: at childbirth (maximum 10 months)
Severe preeclampsia is defined by preeclampsia with at least one of the following criteria : * severe hypertension (PAS ≥ 160 mmHg et/ou PAD ≥ 110 mmHg) * Renal impairment with: oliguria \<500 ml / 24h or creatinine\> 135 μmol / L or proteinuria\> 5 g/d * acute lung edema or persistent epigastric bar or HELLP syndrome * eclampsia or rebellious neurological disorders (visual disturbances, polykinetic ROT, headache), * thrombocytopenia \<100 G / L * Retro Placental Hematoma (HRP) or fetal repercussion.
次要结局
未报告次要终点