COMPARATIVE EVALUATION OF LOCAL DRUG DELIVERY GEL CONTAING EXTRACTS OF MURRAYA KOENIGII WITH THAT OF CHLORHEXIDINE GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN MANAGEMENT OF MODERATE CHRONIC PERIODONTITIS : A RANDOMIZED CONTROLLED TRIAL.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- efficacy of Murraya Koenigii gel in patients with Moderate Chronic Periodontitis as an adjunct to scaling and root planing.
研究概览
简要总结
Chlorhexidine (CHX) is one of the most effective antimicrobial agents for plaque control. Local side effects associated with the use of chlorhexidine induce tooth staining, alteration of taste sensation and costly to the patient. Despite the immense benefit of chlorhexidine gluconate as an antiplaque agent, the search continues for active ingredients that could prevent dental inflammation without affecting the biological equilibrium within the oral cavity. Currently, use of herbal products in dentistry is increasing. This can be attributed to their ease of availability, low cost, and fewer side effects. One such herb with wide medicinal importance is Murraya Koenigii, commonly known as curry leaves. It is well established to have antimicrobial, antiemetic, antidiabetic, antiulcer, antioxidative, cytotoxic, and phagocytic activity. Chlorophyll component in curry leaves has been reported as an anticariogenic agent and it also helps to reduce halitosis. The antibacterial effect of Murraya Koenigii extract has been proven to be effective against an array of Gram-positive, Gram-negative periodontal pathogens. Therefore, Murraya Koenigii extract mouth rinse has been used as an alternative to chlorhexidine mouthwash.
To the best of our knowledge no such study has been carried out comparing the use of Murraya Koenigii in gel form as a local drug delivery agent in the management of Chronic periodontitis. Therefore, the aim of this study will be to assess the efficacy of Murraya Koenigii gel as a local delivery agent in the management of moderate chronic periodontitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with pocket probing depth ≥ 5mm with localized/generalized periodontitis not indicated for surgery.
排除标准
- •Patients who received any antibiotic therapy in the last 6 months.
- •Patients who received any chemotherapeutic mouth rinses/oral irrigation during the past 1 month.
- •Patients who received any surgical or nonsurgical periodontal therapy, 6 months prior to the start of the study.
- •Patients with allergies to any of medications which will be used in the study.
- •Pregnant or Lactating women.
- •Patients who are smokers/alcoholic.
结局指标
主要结局
efficacy of Murraya Koenigii gel in patients with Moderate Chronic Periodontitis as an adjunct to scaling and root planing.
时间窗: 30th day, 90th day
次要结局
- efficacy of Murraya Koenigii gel over chlorhexidine gel in patients with Moderate Chronic Periodontitis as an adjunct to scaling and root planing.(30th day, 90th day)