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临床试验/NCT02830516
NCT02830516已完成不适用

Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods

Stefan Lundin1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2016年6月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
24
试验地点
1
主要终点
Measurement of lung elastance

研究概览

简要总结

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

详细描述

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method in which a PEEP-step is performed with a size which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in anesthetized patients prior to major surgery.

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patient undergoing major surgery during anesthesia and muscle relaxation

排除标准

  • Patient with chronic obstructive lung disease

结局指标

主要结局

Measurement of lung elastance

时间窗: At 1 hour

Comparison of two method for measurements of lung elastance (Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume)

次要结局

未报告次要终点

研究者

发起方
Stefan Lundin
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Stefan Lundin

Professor

Sahlgrenska University Hospital, Sweden

研究点 (1)

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