Role of two autologous blood derived membranes in management of gum recession

Completed

Conditions: Gingival recession,

Registration Number: CTRI/2021/05/033564

Lead Sponsor: Dr Anupama Tadepalli

Brief Summary: Gingival recession is described as apical migration of the free gingival margin relative to the cemento enamel junction leading to root exposure. Research in the South Indian population found approximately 40-68% of the subjects had at least one or more gingival recession defects. Gingival recession is often associated with dentinal hypersensitivity, esthetic issues and also root caries. Periodontal plastic procedures aim to achieve complete root coverage while enhancing aesthetics by integrating mucosa and keratinized gingiva with adjacent tissues.

Platelet concentrates aim at extracting all the potential elements present in the collected blood sample and providing supra-physiological concentration at the surgical site to accelerate the healing process and induce regeneration of lost tissues. The second generation platelet concentrates are formed by natural polymerization during centrifugation, resulting in a three-dimensional fibrin architecture with equilateral junctions mimicking the extracellular matrix structure, offering flexibility and elasticity. Low speed centrifugation concept (LSCC) by Choukroun et al 2014 led to the evolution of Advanced platelet rich fibrins (A-PRF, A-PRF+)

Various invitro and invivo studies had shown the positive outcomes with A-PRF in hard and soft tissue regeneration. However, the potential benefit of advanced platelet rich fibrin in management of gingival recession has not yet been established. The aim of this clinical study was to evaluate and compare the clinical efficacy of L-PRF and A-PRF in the treatment of gingival recession defects.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 30

Inclusion Criteria

Systematically healthy individuals manifesting with millers class I and II recession defects in maxillary anterior teeth and premolars.
Minimum recession depth â‰¥ 2mm.

Exclusion Criteria

Millers class III and 1V gingival recession 2.
Recession sites with probing depth â‰¥ 4mm and teeth with mobility 3.
Teeth with prosthetic restoration 4.
Anaemic patients 5.
Pregnant and lactating women 7.
Patients with poor oral hygiene 8.
Systemic condition /disease/ any medication influencing the periodontal therapy and disease.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Changes in Recession height	Baseline, 3 months, 6 months
2. Root coverage percentage	Baseline, 3 months, 6 months

Secondary Outcome Measures

Name	Time	Method
1. Changes in gingival biotype	Baseline, 6 months

Trial Locations

Locations (1): SRM Dental College
🇮🇳
Chennai, TAMIL NADU, India
SRM Dental College
🇮🇳Chennai, TAMIL NADU, India
Dr Anupama Tadepalli
Principal investigator
9677065517
anupamamds@gmail.com